AUTHOR=Ray Subhasree , Jin Jun-O , Choi Inho , Kim Myunghee 

TITLE=Recent trends of biotechnological production of polyhydroxyalkanoates from C1 carbon sources

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 10 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.907500

DOI=10.3389/fbioe.2022.907500

ISSN=2296-4185

ABSTRACT=Growing concerns over the use of limited fossil fuels and their negative impacts on the ecological niches have facilitated the exploration of alternative routes. The use of conventional plastic material also negatively impacts the environment. One such green alternative is polyhydroxyalkanoates, which are biodegradable, biocompatible, and environmentally friendly. Recently, researchers have focused on the utilization of waste gases particularly those belonging to C1 sources derived directly from industries and anthropogenic activities, such as carbon dioxide, methane, and methanol as the substrate for polyhydroxyalkanoates production. Consequently, several microorganisms have been exploited to utilize waste gases for their growth and biopolymer accumulation. The present review shows the potential of waste gas valorization as a promising solution for the sustainable production of polyhydroxyalkanoates. Key bottlenecks towards the usage of gaseous substrates obstructing their realization on a large scale and the possible technological solutions were also highlighted. Therefore, this article presents a vision of C1 substrate conversion through microbial routes to synthesize polyhydroxyalkanoates, its bioprocessing, applications, and aspects related to the sustainability of the system.