AUTHOR=Dong Chen , Ma Xuehua , Huang Yi , Zhang Yujie , Gao Xiang 

TITLE=Carbon dots nanozyme for anti-inflammatory therapy via scavenging intracellular reactive oxygen species

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.943399

DOI=10.3389/fbioe.2022.943399

ISSN=2296-4185

ABSTRACT=Developing an efficient antioxidant for anti-inflammatory therapy via scavenging reactive oxygen species (ROS) remains a big challenge owing to the insufficient activity and sustainability of conventional antioxidants. Herein, we explored and simply synthesized a biocompatible carbon dots (CDs) nanozyme with excellent scavenging activity of ROS for anti-inflammatory therapy. As expected, CDs nanozyme effectively eliminate many kinds of free radicals including •OH, O2•−, and ABTS+•. Benefiting from multienzyme activities against ROS, CDs nanozyme can decrease the levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), resulting in good anti-inflammatory effect. Taken together, this study not only sheds light on design of bioactive antioxidants but also extends the biomedical application of CDs for anti-inflammatory treatment.