AUTHOR=Zhu Peide , Zhao Xuelin , Zhang Yuqi , Liu Yinping , Zhao Ziyi , Yang Ziji , Liu Xinzhu , Zhang Weiye , Guo Zixuan , Wang Xiao , Niu Yingchun , Xu Meng TITLE=Mn3+/Mn4+ ion-doped carbon dots as fenton-like catalysts for fluorescence dual-signal detection of dopamine JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=Volume 10 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.964814 DOI=10.3389/fbioe.2022.964814 ISSN=2296-4185 ABSTRACT=Carbon dots (CDs), a new zero-dimensional material, have ignited a revolution in the fields of sensing, bioimaging, and biomedicine. However, the difficulty of preparing CDs with Fenton-like catalytic properties has seriously hindered their application in oxidative/reductive biomolecules diagnosis and tumor therapy. Here, an innovative method was successfully established to synthesize Mn3+/Mn4+ ion-doped green fluorescent CDs with Fenton-like catalytic properties using manganese acetate as the manganese source. Specifically, the CDs prepared here were equipped with functional groups of -COOH, NH2, C=O, and Mn-O, offering the possibility to function as a fluorescence sensor. More importantly, the introduction of manganese acetate resulted in the preparation of CDs with Fenton-like catalytic properties, and the dual-response fluorescence detection of dopamine (DA) was realized with linear ranges of 100~275 nM and 325~525 nM, and the detection limits were 3 nM and 12 nM, respectively. In addition, due to the Fenton-like catalytic activity of Mn3+/Mn4+ ion-doped CDs, the cell viability of 143B cells decreased significantly with the increase of CDs content, which could be successfully used for the bioimaging of 143B cells.