AUTHOR=Dong Changchao , Tan Gang , Zhang Guangyan , Lin Wei , Wang Guanglin 

TITLE=The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1133995

DOI=10.3389/fbioe.2023.1133995

ISSN=2296-4185

ABSTRACT=Bone provides a solid barrier for the origin and development of immune cells in the bone marrow. The process of bone regeneration involves the interaction of the skeletal, blood, and immune systems. At the same time, immune cells secrete factors to feedback on the remodeling of the skeletal system. Pathological or traumatic injury of bone tissue involves changes in blood supply, cell behavior, and cytokine expression. Immune cells and their factors play an essential role in repairing foreign bodies in bone injury or implantation of biomaterials, the clearance of dead cells, and the regeneration of bone tissue. This article reviews the bone regeneration application of the bone tissue repair micro-environment in bone cells and immune cells in the bone marrow and the interaction of materials and immune cells.