AUTHOR=Pan Yuqi , Li Yige , Dong Wenjun , Jiang Bowei , Yu Yuhao , Chen Yunsu 

TITLE=Role of nano-hydrogels coated exosomes in bone tissue repair

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1167012

DOI=10.3389/fbioe.2023.1167012

ISSN=2296-4185

ABSTRACT=As the development of nano-material, it is widely applied in different areas. Some nano-materials are designed to be biocompatible and can be used in medical field, playing an important role in disease treatment. 
Exosomes are the nanoscale vesicle with a diameter of 30-200 nm.  Studies have shown that exosome have the effect of angiogenesis, tissue (skin, tendon, cartilage, et al.) repair and reconstruction. Nano-hydrogels are hydrogels with a diameter of 200 nm or less and can be used as the carrier to transport the exosome into the body. 
Some bone defect, bone infection or other complex bone disease are hard to deal with. The emerge of exosome coated nano-hydrogels may bring a new idea to solve these problems, improving the prognosis of patients. This review summarizes the function of nano-hydrogel coated exosome from different origins in bone tissue repair, intending to illustrate the potential use and application of exosomes coated nano-hydrogel in complex bone disease.