AUTHOR=Yu Hongjie , Chen Jianling , Chen Xiuqin , Zhang Tiantian , Li Yuyang , Chen Kuizhi , Peng Yiru , Chen Linying 

TITLE=Morpholinyl silicon phthalocyanine nanoparticles with lysosome cell death and two-photon imaging functions for in vitro photodynamic therapy of cancer cells

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1181448

DOI=10.3389/fbioe.2023.1181448

ISSN=2296-4185

ABSTRACT=The lysosome is an important target for realizing antitumor therapy because of the prominent therapeutic effect of lysosomal cell death on apoptosis- and drug-resistance cancer. Development of multifunctional lysosome-targeting nanoparticles for obtaining efficient cancer treatment is a significantly challenging task. In this paper, a morpholinyl silicon phthalocyanine nanoparticles DSPE@M-SiPc possessing bright two-photon fluorescence, lysosome targeting photodynamic therapy functions are prepared by encapsulating M-SiPc in functional amphiphilic polymers. Two photon fluorescence bioimaging showed that M-SiPc and DSPE@M-SiPc mainly locates in lysosomes after cellular internalization. Upon irradiation, DSPE@M-SiPc effectively generates reactive oxygen species, damages the function of lysosome and subsequently leads to lysosomal cell death. This study brings a bovel insight into the development of a superior effective nanophotosentizer for cancer treatment.