AUTHOR=Zheng Yuwei , Xue Chao , Wang Jing , Chen Xuan , Wang Xiaohui , Wang Yan 

TITLE=Analysis of the correlation between biomechanical properties and corneal densitometry in myopic eyes

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1182372

DOI=10.3389/fbioe.2023.1182372

ISSN=2296-4185

ABSTRACT=Background: To investigate the correlation between corneal biomechanical characteristics (in vitro and in vivo) and corneal densitometry in myopia.
Methods: The Pentacam (Oculus, Wetzlar, Germany) corneal densitometry (CD) and Corvis ST (Oculus, Wetzlar, Germany) exams were conducted prior to surgery for myopic patients who were intended to undergo small-incision lenticule extraction (SMILE). CD values (grayscale units, GSUs), and in vivo biomechanical parameters were obtained. The stromal lenticule was subjected to a uniaxial tensile test to obtain the elastic modulus E in vitro. We exam the correlations among in vivo, in vitro biomechanical characteristics and CD values.
Results: In this study, 37 myopic patients (63 eyes) were included. The mean age of participants was 25.14±6.74 years (range:16-39 years). The mean CD values of the total cornea, anterior layer, intermediate layer, posterior layer, 0-2 mm region and 2-6 mm region were 15.03±1.23 GSU, 20.35±1.98 GSU, 11.76±1.01 GSU, 10.95±0.83 GSU, 15.57±1.12 GSU and 11.94±1.77 GSU, respectively. Elastic modulus E (in vitro biomechanical indicator) was negatively correlated with intermediate layer CD (r=-0.35, P=0.01) and 2-6 mm region CD (r=-0.39, P=0.00). A negative correlation was also found between 0-2 mm central region CD and in vivo biomechanical indicator SP-HC (r=-0.29, P=0.02). 
Conclusions: In myopic patients, densitometry is negatively correlated with biomechanical properties both in vivo and in vitro. With an increase in CD, the cornea deformed more easily.