AUTHOR=Du Bing , Su Yu , Li Dongchen , Ji Shuai , Lu Yao , Xu Yibo , Yang Yanling , Zhang Kun , Li Zhong , Ma Teng 

TITLE=Analysis of risk factors for serous exudation of biodegradable material calcium sulfate in the treatment of fracture-related infections

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1189085

DOI=10.3389/fbioe.2023.1189085

ISSN=2296-4185

ABSTRACT=Objective : To explore the related risk factors of serous
exudation after antibiotic-loaded calcium sulfate treatment of
fracture-related infections and to provide a theoretical basis for
clinical treatment and prevention of serous exudation
complications.  Results : The clinical data of 145 patients with limb
fracture-related infection treated with antibiotic-loaded calcium
sulfate in Xi 'an Honghui Hospital from January 2019 to
December 2022 were retrospectively analyzed. All patients were
diagnosed with fracture-related infection by preoperative
magnetic resonance examination, bacterial culture and gene
detection and received antibiotic-loaded calcium sulfate
implantation. The postoperative serous exudation was recorded
through hospitalization observation, outpatient review or
follow-up. The collected clinical data were sorted out, and the
patient data were divided into serous and non-exudation groups. Firstly, the clinical data of the two groups were compared by
single-factor analysis to screen out the risk factors. Then
multivariate binary Logistic regression analysis determined the
independent and protective risk factors. Conclusion : 1. The probability of serous exudation in patients
with fracture-associated infection after antibiotic-loaded
calcium sulfate surgery was 18.62 %. This complication may
cause a heavier economic and psychological burden on patients;
2. With the increase of bone infection area and the application of
more calcium sulfate, the incidence of serous exudation after
antibiotic-loaded calcium sulfate surgery in patients with the
fracture-related infection will increase, so we should use the
amount of calcium sulfate reasonably on the premise of sufficient
control of infection in clinical work, and the incidence of serous
exudation will also increase due to the recent skin flap surgery
and the thinner soft tissue coverage of calcium sulfate
implantation area ; 3. Under the premise of being able to drain
the drainage from the surgical area, the longer drainage time of
the drainage tube has a positive effect on preventing the
occurrence