AUTHOR=Orban Mostafa , Guo Kai , Yang Hongbo , Hu Xuhui , Hassaan Mohamed , Elsamanty Mahmoud TITLE=Soft pneumatic muscles for post-stroke lower limb ankle rehabilitation: leveraging the potential of soft robotics to optimize functional outcomes JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=Volume 11 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1251879 DOI=10.3389/fbioe.2023.1251879 ISSN=2296-4185 ABSTRACT=A soft pneumatic muscle was developed to replicate the intricate ankle motions crucial for rehabilitation, with a specific focus on the rotational movement along the x-axis that is essential for walking. The design incorporated precise geometrical parameters and air pressure regulation to enable controlled expansion and motion, while the muscle's response was evaluated under pressure conditions ranging from 100-145 kPa. To optimize the muscle design, finite element simulation was employed to analyze its performance in terms of motion range, force generation, and energy efficiency. An experimental platform was created to assess the muscle's deformation, utilizing advanced techniques such as high-resolution imaging and deep-learning position estimation models for accurate measurements. The experimental results demonstrated that, under a pressure of 145 kPa, the y-axis deformation (y-def) reached 165 mm, while the xaxis and z-axis deformations were significantly smaller at 0.056 mm and 0.0376 mm, respectively, highlighting the predominant elongation in the y-axis resulting from pressure actuation. The fabrication process involved silicone-based materials and 3D-printed molds, enabling precise control and customization of muscle expansion and contraction. The soft muscle model featured a single chamber constructed from silicone rubber, and the visually illustrated and detailed geometrical parameters played a critical role in its functionality, allowing systematic manipulation to meet specific application requirements. The simulation and experimental results provided compelling evidence of the soft muscle design's adaptability, controllability, and effectiveness, thus establishing a solid foundation for further advancements in ankle rehabilitation and soft robotics. Incorporating this soft muscle into rehabilitation protocols holds significant promise for 1 M. Orban et al. enhancing ankle mobility and overall ambulatory function, offering new opportunities to tailor rehabilitation interventions and improve motor function restoration.