AUTHOR=Li Zheng , Zhang Yunyang , Ye Qing , Wang Lei , Chen Hui , Xu Chenhui , Wang Peng , Sun Jianfei 

TITLE=Endowing improved osteogenic activities with collagen membrane by incorporating biocompatible iron oxide nanoparticles

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1259904

DOI=10.3389/fbioe.2023.1259904

ISSN=2296-4185

ABSTRACT=Collagen-based scaffolds, renowned for their exceptional biocompatibility, have garnered attention as promising scaffolds for advancing bone tissue regeneration. Nevertheless, these scaffolds possess inherent limitations, such as notably compromised osteo-conductivity and osteo-inductivity.To address this matter, our study focused on enhancing the mechanical properties and osteogenic bioactivities of bovine-derived collagen membranes (CMs) from Achilles tendon by incorporating FDA-approved iron oxide nanoparticles (IONPs), termed as IONPs-CM. Three types of IONPs-CM (IONPs-CM-0.5, IONPs-CM-1, and IONPs-CM-1.5) were constructed by altering the amounts of feeding IONPs. Surface topography analysis demonstrated comparable characteristics between IONPs-CM and neat CM, with the former exhibiting augmented mechanical properties. In vitro evaluations revealed the remarkable biocompatibility of IONPs-CM towards mouse calvarial pre-osteoblast