AUTHOR=Lee Hoyeon , Kim Boyoung , Yun Jiyue , Bae Jinseung , Park Sungsu , Jeon Junseok , Jang Hye Ryoun , Lee Jaecheol , Lee Soah 

TITLE=PIV-MyoMonitor: an accessible particle image velocimetry-based software tool for advanced contractility assessment of cardiac organoids

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 12 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1367141

DOI=10.3389/fbioe.2024.1367141

ISSN=2296-4185

ABSTRACT=We developed an open-source particle image velocimetry-based software program for advanced contractility assessment of various cardiac models. PIV-MyoMonitor enables comprehensive quantitative assessment and advanced visualization of the contractile function across cardiac models, from single cells to 2D monolayers to 3D engineered heart tissues to 3D cardiac organoids. This novel tool can help investigate the biomechanics of cells and tissues for studying cardiovascular physiology and pathology.