AUTHOR=Liu Shan 

TITLE=Self-assembled lipid-based nanoparticles for chemotherapy against breast cancer

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 12 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1482637

DOI=10.3389/fbioe.2024.1482637

ISSN=2296-4185

ABSTRACT=Self-assembled lipid-based nanoparticles have increased therapeutic efficacy and reduced toxic side effects. Breast cancer is a common malignant tumor among women. Conventional drugs such as doxorubicin (DOX) show low therapeutic efficacy and high drug toxicity in antitumor therapy.  This paper survey the research of the self-assembled lipid-based nanoparticles, categorizing them into three groups: self-assembled liposomal nanostructures, self-assembled niosomes, and self-assembled lipid polymer-hybrid nanoparticles. Subsequently, the structural features, operational mechanisms of each group are individually summarized.  Also, the representative drugs of each group are exhibited.