AUTHOR=Wan Longbiao , Yao Xiaoyue , Pan Jiali , Xiang Ziyang , Fu Dongjie , Ye Qingsong , Wu Fei 

TITLE=Crafting the future of bone regeneration: the promise of supramolecular peptide nanofiber hydrogels

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1514318

DOI=10.3389/fbioe.2025.1514318

ISSN=2296-4185

ABSTRACT=Bone tissue engineering has rapidly emerged as an ideal strategy to replace autologous bone grafts, establishing a comprehensive system centered on biomaterial scaffolds, seeding cells, bioactive factors, and biophysical stimulation, thus paving the way for new horizons in surgical bone regeneration. However, the scarcity of suitable materials poses a significant challenge in replicating the intricate multi-layered structure of natural bone tissue. Supramolecular peptide nanofiber hydrogels (SPNHs) have shown tremendous potential as novel biomaterials due to their excellent biocompatibility, biodegradability, tunable mechanical properties, and multifunctionality. Various supramolecular peptides can assemble into nanofiber hydrogels, while bioactive sequences and factors can be embedded through physical adsorption or covalent binding, endowing the hydrogels with diverse biochemical properties. Finally, this review explored the future challenges and prospects of SPNHs in bone tissue engineering, with the aim of providing insights for further advancements in this field.