AUTHOR=Dutra Alves Nathalia Silva , Reigado Gustavo Roncoli , Santos Mayara , Caldeira Izabela Daniel Sardinha , Hernandes Henrique dos Santos , Freitas-Marchi Bruna Leticia , Zhivov Elina , Chambergo Felipe Santiago , Nunes Viviane Abreu 

TITLE=Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1527854

DOI=10.3389/fbioe.2025.1527854

ISSN=2296-4185

ABSTRACT=Significant progress has been made in regenerative medicine for skin repair and rejuvenation. This review examines core technologies including stem cell therapy, bioengineered skin substitutes, platelet-rich plasma (PRP), exosome-based therapies, and gene editing techniques like CRISPR. These methods hold promise for treating a range of conditions, from chronic wounds and burns to age-related skin changes and genetic disorders. Challenges remain in optimizing these therapies for broader accessibility and ensuring long-term safety and efficacy.