AUTHOR=Liu Chang , Rivera Ruiz Alejandro , Zhang Yingchun , Zimmern Philippe , Li Zhengwei TITLE=Emergent biotechnology applications in urology: a mini review JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=Volume 13 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1539126 DOI=10.3389/fbioe.2025.1539126 ISSN=2296-4185 ABSTRACT=Technological advances have significantly impacted the field of urology, providing innovative solutions for diagnosis, treatment, and management of various urological disorders and diseases. This article highlights four groundbreaking technologies: whole-cell biosensors, optogenetic interventions for neuromodulation, bioengineered urinary bladder, and 3D bioprinting. Each technology plays a crucial role in enhancing patient care and improving clinical outcomes in urology. Advances in these fields underscore a shift towards precision diagnostics, personalized treatments, and enhanced regenerative strategies, ultimately aiming to enhance patient outcomes and address unmet clinical needs in urological diseases.