AUTHOR=Zhao Tian , Weng Yi , Li Ning , Gao Yiming TITLE=Clinical evaluation of computer-aided design and three-dimensional printing for completely edentulous mandibular custom tray fabrication: assessing clinician satisfaction JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=Volume 13 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1556651 DOI=10.3389/fbioe.2025.1556651 ISSN=2296-4185 ABSTRACT=This study evaluates prosthodontists’ satisfaction and efficiency of custom tray fabrication methods in completely edentulous mandibular jaw patients. A digital workflow was established, incorporating 3D scanning for preliminary impressions, CAD for designing border extensions and ensuring uniform 3D space, and 3D printing for tray fabrication. Three methods were compared: CAD/3D printing, light-cured resin, and impression compound trimming. Prosthodontist satisfaction was assessed using a visual analog scale, and manual fabrication time was analyzed. Dislocation tests were performed to evaluate tray retention. The CAD/3D printing method achieved the highest satisfaction across most parameters (P < 0.05), the best stability and retention (P < 0.05), and significantly reduced manual fabrication time (P < 0.05). The light-cured resin method showed moderate performance, while the impression compound trimming method scored lowest. The CAD/3D printing technique enhances satisfaction, precision, and efficiency, demonstrating significant potential for optimizing prosthodontic workflows. Further exploration in broader clinical applications is recommended.