AUTHOR=Fan Tingting , Wang Jinhang , Wang Xu , Chen Xi , Zhao Dongliang , Xie Fengjie , Chen Guangxin 

TITLE=Integrated multidisciplinary approach to aneurysm hemodynamic analysis: numerical simulation, in Vitro experiment, and deep learning

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1602190

DOI=10.3389/fbioe.2025.1602190

ISSN=2296-4185

ABSTRACT=Aneurysm, as life-threatening vascular pathologies, are significantly influenced by hemodynamic factors in their development. The combine of numerical simulation and in vitro experiment have laid the foundation for high-precision hemodynamic analysis, while the integration of deep learning technologies has significantly enhanced computational efficiency. However, current researches still face challenges such as limitations in biomimetic materials, and incomplete understanding of mechano-biological coupling mechanisms. In this review, we systematize traditional and emerging methodologies characterizing hemodynamic perturbations across the pathophysiological continuum of aneurysmal expansion, rupture, and thrombosis progression. This review aims to (1) elucidate mechanistic underpinnings of aneurysm destabilization, (2) inspire people to establish standardized quantification protocols for hemodynamic analysis, and (3) pave the way for patient-specific risk stratification enabling data-driven clinical interventions.