AUTHOR=Rubinstein Clara , Levitus Gabriela , Vicien Carmen , Modena Natalia Andrea , Ruzal Sandra , Vesprini Facundo , Lewi Dalia Marcela , Caminoa Cecilia , Malacarne Maria Fabiana , Francescutti Nerina , Amaturo Juan Ignacio TITLE=Genetically modified microorganisms for agricultural use: an opportunity for the advancement of risk assessment criteria in Argentina JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=Volume 13 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1612226 DOI=10.3389/fbioe.2025.1612226 ISSN=2296-4185 ABSTRACT=The development and use of biologicals in agriculture is of growing interest globally. The potential of these tools to increase and protect yield complementing other tools has stimulated the interest of developers. Agricultural countries like Brazil and Argentina in Latin America have extensive experience with the use of biologicals for biocontrol and as seed inoculants. The last decade has seen the number of bio-based startups grow in the region, many of those dedicated to the development of microbial based bio-inputs. The potential for improving the efficacy and functionality of these products by means of gene technologies is very promising; however, the regulatory oversight of these innovations needs adaptation to become fit for purpose. The Biotechnology Working Group at ICCAS identified the need for a science-based discussion on this matter and considered alternatives to the current paradigm, developed over 30 years ago for transgenic plants.