AUTHOR=Mazzoli Marilena , Gasparotti Emanuele , Vignali Emanuele , Haxhiademi Dorela , Celi Simona TITLE=Impact of aortic morphology on VA-ECMO performance: a combined statistical shape modeling and CFD approach JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=Volume 13 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1620897 DOI=10.3389/fbioe.2025.1620897 ISSN=2296-4185 ABSTRACT=IntroductionThe veno-arterial extracorporeal membrane oxygenation (VA ECMO) system is a temporary support procedure to provide oxygenated blood in patients with cardiac or respiratory failure. Despite being widely used in clinical reality, the VA ECMO has some well-known flaws, like the formation of a 'watershed zone' as a consequence of the mixing of native blood from the left ventricle and retrograde oxygenated blood from the ECMO pump. A deeper knowledge of the watershed zone behavior could contribute to better defining the oxygenation balancing for the patient.MethodsFrom this concept, this study proposes a numerical approach combined with Statistical Shape Modeling (SSM) to evaluate the effect of aortic morphology variations on the different conditions of VA ECMO support. In particular, a new SSM approach was adopted to define 48 synthetic aortic morphologies starting from patient-specific computed tomography datasets. After assessing the morphological differences, the first 10 modes were selected to generate volumetric meshes for a Computational Fluid Dynamics (CFD) analysis. A total of 20 cases were simulated in the healthy conditions, while four cases were simulated with a 70% reduction of cardiac output and three different levels of ECMO support (0, 4, and 6 L/min).ResultsFrom the simulated results, it was possible to assess the behavior of the watershed zone as a function of aortic morphological parameters and ECMO level.DiscussionThe results confirmed the significant effect of ECMO level on the position and distribution of the zone.