AUTHOR=Steitz Marvin , Khan Mahamuda Badhon , Breitenstein-Attach Alexander , Warnack Boris , Edelmann Frank , Berger Felix , Schmitt Boris 

TITLE=Mechanotransduction of autotransplants: remodeling potential of heart valves from autologous pericardial tissue

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1680107

DOI=10.3389/fbioe.2025.1680107

ISSN=2296-4185

ABSTRACT=Current commercial heart valve prostheses are non-living structures, either derived from artificial materials (mechanical valves) or foreign biological materials (xeno- or homo-graft). Since the use of viable tissue with native-like properties is essential for a heart valve with self-regulation properties, autologous collagen-based tissue can be considered a promising alternative material. While the extracellular matrix of pericardial tissue offers a solid foundation, it is the interstitial cells that play a crucial role in ensuring long-term durability. This review explores the mechanotransduction capabilities of autologous tissue as a replacement material for living heart valves with regenerative potential.