Frontiers in Bioengineering and Biotechnology

Original Research

Published on 20 Nov 2024

Protein trans-splicing: optimization of intein-mediated GFP assembly as a model for the development of gene therapy

in Cell and Gene Therapy

Andrew Brovin
Ekaterina Minskaia
Matvei Sabantsev
Sergey Chuvpilo
Alexander Karabelsky

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1488912

2,815 views
1 citation

Original Research

Published on 11 Nov 2024

Morphogen-driven differentiation is precluded by physical confinement in human iPSCs spheroids

in Cell and Gene Therapy

Haneen S. Alsehli
Errin Roy
Thomas Williams
Alicja Kuziola
Yunzhe Guo
Cecile A. Dreiss
Jeremy B.A. Green
Eileen Gentleman
Davide Danovi

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1467412

1,881 views

Original Research

Published on 01 Oct 2024

An improved high-resolution method for quantitative separation of empty and filled AAV8 capsids by strong anion exchange HPLC

in Cell and Gene Therapy

Samantha Schrecke
Kevin McManus
Cassandra Moshfegh
Jessica Stone
Thuy-Uyen Nguyen
Gustavo Rivas
Ismaeel Muhamed
Daniel A. J. Mitchell

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1436857

2,651 views
1 citation

Original Research

Published on 20 Aug 2024

Assessing a single-cell multi-omic analytic platform to characterize ex vivo-engineered T-cell therapy products

in Cell and Gene Therapy

Maryam Moshref
Jerry Hung-Hao Lo
Andrew McKay
Julien Camperi
Joseph Schroer
Norikiyo Ueno
Shu Wang
Saurabh Gulati
Somayeh Tarighat
Steffen Durinck

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1417070

9,194 views
1 citation

Review

Published on 29 Jul 2024

The application potential of iMSCs and iMSC-EVs in diseases

in Cell and Gene Therapy

Xin Zhou
Jinyu Liu
Feifeng Wu
Jueyi Mao
Yang Wang
Junquan Zhu
Kimsor Hong
Haotian Xie
Binbin Li
Xinying Qiu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1434465

2,908 views
3 citations

Systematic Review

Published on 22 Jul 2024

Effectiveness and mechanisms of mesenchymal stem cell therapy in preclinical animal models of hepatic fibrosis: a systematic review and meta-analysis

in Cell and Gene Therapy

Xuesong Wang
Yue Wang
Wenming Lu
Jiayang Qu
Yang Zhang
Junsong Ye

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1424253

2,304 views
1 citation

Original Research

Published on 10 Jul 2024

Effects of buffer composition and plasmid toxicity on electroporation-based non-viral gene delivery in mammalian cells using bursts of nanosecond and microsecond pulses

in Cell and Gene Therapy

Eivina Radzevičiūtė-Valčiukė
Jovita Gečaitė
Austėja Balevičiūtė
Anna Szewczyk
Augustinas Želvys
Barbora Lekešytė
Veronika Malyško-Ptašinskė
Eglė Mickevičiūtė
Paulina Malakauskaitė
Julita Kulbacka

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1430637

2,400 views

Original Research

Published on 05 Jul 2024

11β hydroxysteroid dehydrogenase type 1 transgenic mesenchymal stem cells attenuate inflammation in models of sepsis

in Cell and Gene Therapy

Rahul Y. Mahida
Zhengqiang Yuan
Krishna K. Kolluri
Aaron Scott
Dhruv Parekh
Rowan S. Hardy
Michael A. Matthay
Gavin D. Perkins
Sam M. Janes
David R. Thickett

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1422761

3,200 views

Original Research

Published on 18 Jun 2024

Use of CRISPRoff and synthetic Notch to modulate and relay endogenous gene expression programs in engineered cells

in Cell and Gene Therapy

Shuqun Shi
Catherine A. Hamann
Joanne C. Lee
Jonathan M. Brunger

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1346810

2,594 views
1 citation

Original Research

Published on 31 May 2024

Non-viral expression of chimeric antigen receptors with multiplex gene editing in primary T cells

in Cell and Gene Therapy

Dan Cappabianca
Jingling Li
Yueting Zheng
Cac Tran
Kassandra Kasparek
Pedro Mendez
Ricky Thu
Travis Maures
Christian M. Capitini
Robert Deans

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1379900

4,711 views

Review

Published on 24 May 2024

Designing cytochrome P450 enzymes for use in cancer gene therapy

in Cell and Gene Therapy

Saskya E. Carrera-Pacheco
Alexander Mueller
Juan A. Puente-Pineda
Johana Zúñiga-Miranda
Linda P. Guamán

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1405466

11,500 views
7 citations

Review

Published on 23 May 2024

Advances in ex vivo expansion of hematopoietic stem and progenitor cells for clinical applications

in Cell and Gene Therapy

André Branco
Janakiram Rayabaram
Cláudia C. Miranda
Ana Fernandes-Platzgummer
Tiago G. Fernandes
Suchitra Sajja
Cláudia L. da Silva
Mohan C. Vemuri

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1380950

5,036 views
1 citation

Systematic Review

Published on 06 May 2024

Evaluating the efficacy of mesenchymal stem cells for diabetic neuropathy: A systematic review and meta-analysis of preclinical studies

in Cell and Gene Therapy

Yu Li
Guangren Yue
Shuying Yu
Xinhao Cheng
Yilin Cao
Ximei Wang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1349050

2,091 views
2 citations

Original Research

Published on 26 Apr 2024

Cell-free fat extract regulates oxidative stress and alleviates Th2-mediated inflammation in atopic dermatitis

in Cell and Gene Therapy

Zexin Fu
Qinhao Gu
Lu Wang
Lulu Chen
Liuyi Zhou
Qiang Jin
Ting Li
Ye Zhao
Sufan Wu
Xuejiao Luo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1373419

2,392 views

Original Research

Published on 17 Apr 2024

Low-intensity pulsed ultrasound promotes the osteogenesis of mechanical force-treated periodontal ligament cells via Piezo1

in Cell and Gene Therapy

Fu Zheng
Tong Wu
Feifei Wang
Huazhi Li
Hongyi Tang
Xinyu Cui
Cuiying Li
Yixiang Wang
Jiuhui Jiang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1347406

4,118 views
7 citations

Original Research

Published on 09 Apr 2024

Harnessing accurate mitochondrial DNA base editing mediated by DdCBEs in a predictable manner

in Cell and Gene Therapy

Jiaxin Qiu
Haibo Wu
Qin Xie
Yuxiao Zhou
Yining Gao
Junbo Liu
Xueyi Jiang
Lun Suo
Yanping Kuang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1372211

2,090 views
3 citations