Frontiers in Bioengineering and Biotechnology

Original Research

Accepted on 07 Aug 2025

Alternating 2D and 3D Culture Reduces Cell Size and Extends the Lifespan of Placenta-Derived Mesenchymal Stem Cells

in Cell and Gene Therapy

Ying Pan
Li Han
Yakun Yang
Xinran Wu
Aijun Wang
Liangqi Xie
Wuqiang Zhu
Shue Wang
Yuguo Lei

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1632810

Original Research

Published on 06 Aug 2025

Macula densa cell angiogenic mechanisms and their therapeutic potential in kidney disease

in Cell and Gene Therapy

Georgina Gyarmati
Dorinne Desposito
Anne Riquier-Brison
Alejandra Becerra Calderon
Greta Trogen
Audrey Izuhara
Michifumi Yamashita
János Peti-Peterdi

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1606230

198 views

Original Research

Published on 05 Aug 2025

Poly-ether-ether-ketone wear particles induce a pro-inflammatory phenotype in a human monocytic cell line

in Cell and Gene Therapy

Shannon Jamieson
Philip Hyde
Patrick Card
David Deehan
John Kirby
Alison Tyson-Capper

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1507248

447 views

Original Research

Accepted on 04 Aug 2025

Enhancing Lentiviral Production for WAS Gene Therapy: A Comparative Analysis of Stable Producer Cell Lines evaluating Flatware system and Adherent Bioreactors in Perfusion Mode

in Cell and Gene Therapy

Parameswari Singh
Nikki Indresh Lal
Monica Terrao
Sarah Schwingal
Martina Biserni
Florian Aeschimann
Andrea Strauch
Herbert Dersch
Angel Jaramillo
Andreas Gille

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1648028

144 views

Original Research

Published on 25 Jul 2025

Regulation of RHBDD1 in the invasion of esophageal cancer cells via ELK3/Wnt/β-catenin signaling pathway

in Cell and Gene Therapy

Bing Xu
Hui Chen
Xinchen Sun
Hongyan Cheng
Kavimbi Chipusu
Wei Hua
Tingting Chen

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1604859

645 views

Original Research

Published on 23 Jul 2025

Comprehensive analysis of pyroptosis-related genes in psoriasis and targeted gene editing of CASP1 and CASP5 using lipid nanoparticles to alleviate skin inflammation

in Cell and Gene Therapy

Gexiao Xu
Guanyi Ma
Jiachen Sun
Xiaoyan Yu
Jie Sun
Bing Gao

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1639869

1,109 views

Systematic Review

Accepted on 21 Jul 2025

Meta-analysis of Mesenchymal Stem Cell Therapy for Intrauterine Adhesions: A Comprehensive Consideration of Efficacy and Safety

in Cell and Gene Therapy

Jiawei Gao
Xinyue Zhou
Nan Jiang
Yongjuan Zhang
Jianpeng Han
Tianyu Jia
Yanbiao Jiang
Xiaoling Ma
Haofei Shen

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1619778

180 views

Original Research

Published on 14 Jul 2025

A pilot study of healing critical-sized calvarial defects by LL-37-generated monoosteophils

in Cell and Gene Therapy

Keith Le
Huinan Liu
Chaoxing Zhang
Zhuo Li
Tove Olafsen
Yuman Fong
John E. Shively
Zhifang Zhang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1583496

1,186 views

Original Research

Published on 04 Jul 2025

Cell retention in scalable, perfusion-based mesenchymal stem cell expansion processes: a proof of concept

in Cell and Gene Therapy

Samuel Lukas Schneider
Abiram Gopalakrishnan
Misha Alexander Teale
Regine Eibl

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1611703

1,473 views

Correction

Published on 26 Jun 2025

Correction: An engineered adipose formulation decreases hepatic inflammation and fibrosis in a rodent model of metabolic dysfunction-associated steatotic liver disease

in Cell and Gene Therapy

Youngshim Choi
Yinyan Ma
Samson Tom
Alla Danilkovitch
Liqing Yu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1642526

706 views

Original Research

Published on 25 Jun 2025

Closed-system manufacturing of therapeutic NK cells using automated cell enrichment and concentration processes enables scalable, robust and cost-effective solutions

in Cell and Gene Therapy

Nina Kok
Zoë Dekkers
Anica Loos
Thomas Bos
Puck van den Broek
Inge Post
Bertine Niessen
Jan Spanholtz
Volker Huppert
Monica Raimo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1586912

2,021 views

Review

Published on 23 Jun 2025

Lung cancer vaccine strategies: exploring the spectrum from traditional to RNA-based platforms

in Cell and Gene Therapy

Alireza Pazoki
Sepehr Dadfar
Atefe Alirezaee
Valentyn Oksenych
Dariush Haghmorad

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1617352

1,893 views

Review

Published on 13 Jun 2025

Mesenchymal stem cells derived extracellular vesicles for chronic kidney disease: pleiotropic mechanisms of actions of a versatile therapy

in Cell and Gene Therapy

Elena Ceccotti
Marco Quaglia
Giovanni Camussi
Stefania Bruno

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1612193

1,957 views

Review

Published on 09 Jun 2025

Chondroitinase ABC in spinal cord injury: advances in delivery strategies and therapeutic synergies

in Cell and Gene Therapy

Rachel Santana Cunha
Erik Aranha Rossi
Thaís Alves de Santana
Zaquer Suzana Munhoz Costa-Ferro
Bruno Solano de Freitas Souza

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1604502

2,040 views

Original Research

Published on 06 Jun 2025

An engineered adipose formulation decreases hepatic inflammation and fibrosis in a rodent model of metabolic dysfunction-associated steatotic liver disease

in Cell and Gene Therapy

Youngshim Choi
Yinyan Ma
Samson Tom
Alla Danilkovitch
Liqing Yu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1579062

1,737 views

Review

Published on 30 May 2025

Challenges and future perspectives in using mesenchymal stem cells for efficient bone fracture healing

in Cell and Gene Therapy

Dong Han
Weiwei Liu
Jinpeng Gong
Yupeng Ma
Zhengwen Sun

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1568914

1,875 views