AUTHOR=Keenum Ishi , Jackson Scott A. , Eloe-Fadrosh Emiley , Schriml Lynn M. TITLE=A standards perspective on genomic data reusability and reproducibility JOURNAL=Frontiers in Bioinformatics VOLUME=Volume 5 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1572937 DOI=10.3389/fbinf.2025.1572937 ISSN=2673-7647 ABSTRACT=Genomic and metagenomic sequence data provides an unprecedented ability to re-examine findings, offering a transformative potential for advancing research, developing computational tools, enhancing clinical applications, and fostering scientific collaboration. However, effective and ethical reuse of genomics data is hampered by numerous technical and social challenges. The International Microbiome and Multi’Omics Standards Alliance (IMMSA, https://www.microbialstandards.org/) and the Genomic Standards Consortium (GSC, https://gensc.org) hosted a 5-part seminar series “A Year of Data Reuse” in 2024 to explore challenges and opportunities of data reuse and reproducibility across disparate domains of the genomic sciences. Addressing these challenges will require a multifaceted approach, including common metadata reporting, clear communication, standardized protocols, improved data management infrastructure, ethical guidelines, and collaborative policies that prioritize transparency and accessibility. We offer strategies to enable responsible and technically feasible data reuse, recognition of data reproducibility challenges, and emphasizing the importance of cross-disciplinary efforts in the pursuit of open science and data-driven innovation.