Frontiers in Bioinformatics | Genomic Analysis section | New and Recent Articles https://www.frontiersin.org/journals/bioinformatics/sections/genomic-analysis RSS Feed for Genomic Analysis section in the Frontiers in Bioinformatics journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-13T06:08:48.50+00:00 60 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1829278 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1829278 <![CDATA[Preoperative APOE and Alzheimer’s disease polygenic risk profiling for perioperative neurocognitive disorders]]> 2026-05-12T00:00:00Z Review Mengquan TanJiling ZengHuixian ZhouShilin YangTong WangMeiling ZhongTongyu WangZheng LiuYaling DaiSiyuan Song https://www.frontiersin.org/articles/10.3389/fbinf.2026.1810235 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1810235 <![CDATA[A machine learning-derived genomic dataset from bacteria frequently reported as probiotics]]> 2026-04-22T00:00:00Z Brief Research Report Diego Lucas Neres RodriguesPedro Alexandre SodrzeieskiSandrine AugerJean-Marc ChatelAna Maria Benko-IsepponVasco AzevedoSiomar de Castro SoaresFlávia Figueira Aburjaile https://www.frontiersin.org/articles/10.3389/fbinf.2026.1767204 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1767204 <![CDATA[Diversity and evolution of quorum-sensing systems in Rhizobium]]> 2026-04-17T00:00:00Z Original Research Ivana Blancas-NavaErick Cruz-SantiagoGabriela GuerreroRosa-Maria Gutierrez-RiosMiguel A. Cevallos https://www.frontiersin.org/articles/10.3389/fbinf.2026.1743474 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1743474 <![CDATA[Bulk RNA-seq datasets analysis integration identifies robust drought-responsive genes and functional networks in Eucalyptus grandis]]> 2026-04-10T00:00:00Z Original Research João Vítor Aires-TeixeiraNivea Maria Pereira LimaRenato Almeida SarmentoGabriel Quintanilha-PeixotoKellen Kauanne Pimenta de Oliveira https://www.frontiersin.org/articles/10.3389/fbinf.2026.1736501 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1736501 <![CDATA[Integrated molecular dynamics elucidation of TP53 H179 zinc-binding variants: genomic and structural characterization across NSCLC subtypes]]> 2026-04-10T00:00:00Z Original Research Ankur DattaC. George Priya Doss A was the predominant single-nucleotide substitution observed, with TP53 gene mutations present in 50% of LUAD and 81% of LUSC cases. All five H179 (Y/R/N/L/D) variants exhibited distinct conformational signatures and resulted in compromised protein stability. Contact maps indicated altered residue-level interaction patterns in the mutants as compared to and the wildtype. The energy landscape of the mutants was also observed to be altered in comparison to the wildtype. Structural perturbations were evident in L1 and L2 loops, indicating that these regions are involved in mutation-induced structural plasticity.DiscussionThe results observed underscore the pathogenic potential of His179 mutations within the p53 Zinc-binding motif. The findings highlight the critical role of the Zinc-binding motif in maintaining p53’s conformational fidelity and suggest that specific substitutions may differentially modulate its tumor-suppressive function.]]> https://www.frontiersin.org/articles/10.3389/fbinf.2026.1677453 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1677453 <![CDATA[Bioinformatics strategies and biomarker refinement using high-throughput transcriptome data in transplantation]]> 2026-04-08T00:00:00Z Original Research Oliver P. GüntherKaren R. SherwoodFranz FenningerRobert F. BalshawAndreas SchererZsuzsanna HollanderRaymond NgJanet Wilson-McManusW. Robert McMasterBruce M. McManusPaul A. Keown https://www.frontiersin.org/articles/10.3389/fbinf.2026.1751616 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1751616 <![CDATA[Development and validation of a pipeline for the systematic search for new HLA alleles in WGS data]]> 2026-04-07T00:00:00Z Original Research Eugene AlbertAndrei DeviatkinDaria SmirnovaMary WoroncowGauhar ZobkovaOlga MityaevaAnna SmirnovaViktor BogdanovPavel Volchkov https://www.frontiersin.org/articles/10.3389/fbinf.2026.1770550 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1770550 <![CDATA[Japanese genomes for pharmacogenomics: primary and secondary pipelines for population-specific insights]]> 2026-03-19T00:00:00Z Brief Research Report Charles W. CrawfordYuka NakanoMarika HayashiAntony IbrahimIssei KonoIri Sato-BaranTakeshi Ozeki https://www.frontiersin.org/articles/10.3389/fbinf.2026.1727493 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1727493 <![CDATA[Identification of key genes in chickpea transcriptomics and the development of ChickpeaOmicsR as a comprehensive resource to advance breeding and genomic studies]]> 2026-03-10T00:00:00Z Original Research Alsamman M. AlsammanKhaled H. MousaAsmaa E. Abd El-HakDoaa A. KorkarAnas M. SaedwiSandy KhaledAl-Sayed Al-SoudyAchraf El AllaliZakaria KehelMorad M. Mokhtar https://www.frontiersin.org/articles/10.3389/fbinf.2025.1750649 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1750649 <![CDATA[Mutational insights and in silico characterization of NEK family kinases in OSCC patients from the Pakistani population]]> 2026-02-04T00:00:00Z Original Research Fouzia NawabWafa NaeemSadia FatimaMuhammad Uzair KhanAamir MehmoodSadia NawabIshaq KhanHaseena NawazHilal AhmadAli Talha KhalilIshtiaq Ahmad KhanMuhammad IrfanMohammed AloriniSyed Ali KhurramAsif Ali https://www.frontiersin.org/articles/10.3389/fbinf.2026.1740722 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1740722 <![CDATA[GPXplore: an intelligent computational framework for precise gene promoter extraction]]> 2026-02-03T00:00:00Z Original Research Shruti GodaraSamarth GodaraShbana BegamAnil Kumar Singh https://www.frontiersin.org/articles/10.3389/fbinf.2025.1703356 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1703356 <![CDATA[REST missense mutations reveal disrupted Re1 motif binding and co-repressor interactions in uterine fibroids]]> 2026-01-12T00:00:00Z Original Research Srineevas SriramChandresh PalanichamyP. T. SubashManshi Kumari GuptaC. Sudandiradoss https://www.frontiersin.org/articles/10.3389/fbinf.2025.1694924 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1694924 <![CDATA[A Transformers-based framework for refinement of genetic variants]]> 2026-01-05T00:00:00Z Original Research Omar AbdelwahabDavoud Torkamaneh https://www.frontiersin.org/articles/10.3389/fbinf.2025.1691056 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1691056 <![CDATA[A novel and accelerated method for integrated alignment and variant calling from short and long reads]]> 2026-01-05T00:00:00Z Original Research Jinnan HuDonald FreedHanying FengHong ChenZhipan LiHaodong Chen https://www.frontiersin.org/articles/10.3389/fbinf.2025.1671693 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1671693 <![CDATA[Identification and functional analysis of hub genes in knee osteoarthritis via bioinformatics and experimental validation]]> 2025-12-17T00:00:00Z Original Research Shanyong JiangJingjing CaoJianshu LuJianxiao LiangLianxin LiYanqiang SongJincheng GaoBaoen Jiang https://www.frontiersin.org/articles/10.3389/fbinf.2025.1708800 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1708800 <![CDATA[Pan-cancer analyses identify oncogenic drivers, expression signatures, and therapeutic vulnerabilities in RHO GTPase pathway genes]]> 2025-12-17T00:00:00Z Original Research Rubén FernándezL. Francisco Lorenzo-MartínVíctor QuesadaXosé R. Bustelo https://www.frontiersin.org/articles/10.3389/fbinf.2025.1695217 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1695217 <![CDATA[Subtractive genomic approach to uncover novel drug targets in Salmonella typhimurium and computational screening of food-based polyphenols as inhibitors]]> 2025-12-03T00:00:00Z Original Research Mohammed Naveez ValathoorSubhashree VenugopalAnand Prem Rajan https://www.frontiersin.org/articles/10.3389/fbinf.2025.1680578 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1680578 <![CDATA[Functional and structural impacts of oncogenic missense variants on human polo-like kinase 1 protein]]> 2025-12-02T00:00:00Z Original Research Gayatri MunieswaranVenkatraman Manickam https://www.frontiersin.org/articles/10.3389/fbinf.2025.1690229 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1690229 <![CDATA[Computational analysis of transcriptome data and mapping of functional networks in Parkinson’s disease]]> 2025-11-19T00:00:00Z Brief Research Report Konstantinos PerperidisThemis P. ExarchosAristidis G. VrahatisPanagiotis VlamosMarios G. Krokidis https://www.frontiersin.org/articles/10.3389/fbinf.2025.1690766 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1690766 <![CDATA[Multi-marker comparative analysis of 18S, ITS1, and ITS2 primers for human gut mycobiome profiling]]> 2025-11-19T00:00:00Z Methods Hiba OrsudSumaya ZoughborFatima AlDhaheriKhalid HajissaManar RefaeySuad AjabKhaled AlswaiderNora MohamedObaid AlkaabiZakeya Al Rasbi