Frontiers in Bioinformatics | Integrative Bioinformatics section | New and Recent Articles https://www.frontiersin.org/journals/bioinformatics/sections/integrative-bioinformatics RSS Feed for Integrative Bioinformatics section in the Frontiers in Bioinformatics journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-13T23:04:45.203+00:00 60 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1722578 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1722578 <![CDATA[Predicting anthropometric body composition variables using 3D optical imaging and machine learning]]> 2026-05-13T00:00:00Z Original Research Gyaneshwar AgrahariKiran BistMonika PandeyJacob KapitaZachary JamesJackson KnoxSteven HeymsfieldSophia RamirezPeter WolenskiNadejda Drenska https://www.frontiersin.org/articles/10.3389/fbinf.2026.1795889 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1795889 <![CDATA[Comparative transcriptomics and computational drug discovery identify ASPM as a key oncogenic driver and therapeutic target in hepatocellular carcinoma]]> 2026-05-07T00:00:00Z Original Research Pan LiAiye GuoMingJing ZhaoGuangHui Chen https://www.frontiersin.org/articles/10.3389/fbinf.2026.1803111 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1803111 <![CDATA[Delineating novel diagnostic biomarkers and therapeutic targets for oral submucosal fibrosis: an integrative multi-omics and machine learning approach]]> 2026-05-04T00:00:00Z Original Research Chinmay Nitin MokalPiyush Agrawal https://www.frontiersin.org/articles/10.3389/fbinf.2026.1811916 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1811916 <![CDATA[On the optimization of copy number variations representation in pangenome graphs]]> 2026-05-01T00:00:00Z Original Research Mirko CoggiLorenzo BasileBeatrice BranchiniGabriele AmodeoGuido Walter Di DonatoMarco D. Santambrogio https://www.frontiersin.org/articles/10.3389/fbinf.2026.1841924 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1841924 <![CDATA[Correction: An integrated automated deep learning framework for annotating tumor-infiltrating lymphocytes in lung adenocarcinoma pathology]]> 2026-04-30T00:00:00Z Correction Xia LiKang-Lai WeiZhao-Quan HuangZi-Yan Huang https://www.frontiersin.org/articles/10.3389/fbinf.2026.1784287 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1784287 <![CDATA[Comprehensive genomics, systems, and structural assessment for novel target identification in penicillin-resistant Streptococcus pneumoniae]]> 2026-04-29T00:00:00Z Original Research Avani PanickarSuvitha AnbarasuAnand ManoharanSudha RamaiahAnand Anbarasu https://www.frontiersin.org/articles/10.3389/fbinf.2026.1803572 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1803572 <![CDATA[Public health risk stratification using hybrid machine learning: a reproducible analysis of performance, stability, and risk attribution]]> 2026-04-23T00:00:00Z Original Research Alejandro Cabrera-AndradeAna Karina ZambranoJoselin García-OrtizWilliam Villegas-Ch https://www.frontiersin.org/articles/10.3389/fbinf.2026.1803237 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1803237 <![CDATA[How benchmarking of bioinformatics tools is essential for informed workflow selection: a case study on SARS-CoV-2 subgenomic RNA detection]]> 2026-04-22T00:00:00Z Original Research Gabriele LeoniMauro PetrilloMan-Hung Eric TangSoren Alexandersen https://www.frontiersin.org/articles/10.3389/fbinf.2026.1800237 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1800237 <![CDATA[Feature representation for explainable CRISPR off-target prediction and base editing efficiency]]> 2026-04-20T00:00:00Z Original Research Faiza HasinMichele MinerviniCorrado MencarGiuseppe VentrellaArianna ConsiglioAlessandro OrroTommaso Selmi https://www.frontiersin.org/articles/10.3389/fbinf.2026.1806975 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1806975 <![CDATA[Geometric multidimensional representation of omic signatures]]> 2026-04-17T00:00:00Z Original Research Higor Almeida Cordeiro NogueiraEnrique Medina-Acosta https://www.frontiersin.org/articles/10.3389/fbinf.2026.1810835 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1810835 <![CDATA[Self-organizing maps for allele specific expression data reconstruction and identification of anomalous genomic regions]]> 2026-04-14T00:00:00Z Original Research Roberto PagliariniFrancesco NascimbenAlberto Policriti https://www.frontiersin.org/articles/10.3389/fbinf.2026.1842628 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1842628 <![CDATA[Correction: Human-associated NDM-5-producing multidrug-resistant Escherichia coli detected in retail beef and pork in Hungary, 2021]]> 2026-04-13T00:00:00Z Correction Frontiers Production Office https://www.frontiersin.org/articles/10.3389/fbinf.2026.1719700 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1719700 <![CDATA[Boolean network and meshless simulations for the comparison of transport and reaction mechanisms arising in one-short tri-exponential and uniform infusion electrochemotherapeutic treatments]]> 2026-03-25T00:00:00Z Original Research Fabián Mauricio Vélez SalazarIván David Patiño ArcilaIsmael E. Rivera MadridMarlon Rincón Fulla https://www.frontiersin.org/articles/10.3389/fbinf.2026.1793862 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1793862 <![CDATA[Human-associated NDM-5-producing multidrug-resistant Escherichia coli detected in retail beef and pork in Hungary, 2021]]> 2026-03-24T00:00:00Z Original Research Mirena IvanovaJoana MourãoJudit SzarvasElif S. TosunNiamh Lacy-RobertsNatasia Rebekka ThornvalZita ZáborckiSzilárd JánosiRaquel Garcia-FierroPierre-Alexandre BeloeilErnesto LiebanaBeatriz GuerraRene S. HendriksenJette S. Kjeldgaard https://www.frontiersin.org/articles/10.3389/fbinf.2026.1792643 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1792643 <![CDATA[Forest-EMCBE: an evolutionary ensemble learning algorithm for multiclass diagnosis of bacterial pneumonia using the CBC dataset]]> 2026-03-18T00:00:00Z Original Research Yimin ShenXiaotian XuXiaoxi HaoCuimin SunWei Lan https://www.frontiersin.org/articles/10.3389/fbinf.2026.1784011 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1784011 <![CDATA[A multi-epitope pan-betacoronavirus vaccine construct predicted to induce broad-spectrum and durable immune responses: an immunoinformatics approach]]> 2026-03-18T00:00:00Z Original Research Anabella Margareth ArapaTrina Ekawati TalleiRinaldi Idroes FatimawaliElly Juliana SuothMaghfirah SavitriAhmad Akroman AdamBeivy Jonathan KolondamChika YamadaRosy Iara Maciel de Azambuja RibeiroAmama RaniMoon Nyeo ParkYoudiil OphinniBonglee Kim https://www.frontiersin.org/articles/10.3389/fbinf.2026.1764743 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1764743 <![CDATA[An integrated automated deep learning framework for annotating tumor-infiltrating lymphocytes in lung adenocarcinoma pathology]]> 2026-03-16T00:00:00Z Original Research Xia LiKang-Lai WeiZhao-Quan HuangZi-Yan Huang 0.96). The implementation of optimized lightweight architectures enables the pipeline to serve as an accessible solution for large-scale WSIs analysis in computational pathology.ConclusionThis study has successfully developed a fully automated annotation pipeline for lung adenocarcinoma WSIs. By generating high-quality annotations of stromal TILs, this pipeline establishes a reliable data foundation for subsequent computational pathology research and facilitates the advancement of artificial intelligence applications in pathology.]]> https://www.frontiersin.org/articles/10.3389/fbinf.2026.1806001 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1806001 <![CDATA[Editorial: Integrating machine learning and AI in biological research: unraveling complexities and driving advancements]]> 2026-03-10T00:00:00Z Editorial Bindu NanduriInimary Toby-Ogundeji https://www.frontiersin.org/articles/10.3389/fbinf.2026.1715377 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1715377 <![CDATA[Evaluating transcriptomic integration for cyanobacterial constraint-based metabolic modelling]]> 2026-02-04T00:00:00Z Original Research Thomas PugsleyGuy HankeChristopher D. P. Duffy https://www.frontiersin.org/articles/10.3389/fbinf.2025.1721028 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1721028 <![CDATA[Essential nucleic acid omics: a theoretical foundation for early-stage users]]> 2026-02-04T00:00:00Z Review Andrew J. MaritanFrank J. Stewart