Frontiers in Bioinformatics | Network Bioinformatics section | New and Recent Articles https://www.frontiersin.org/journals/bioinformatics/sections/network-bioinformatics RSS Feed for Network Bioinformatics section in the Frontiers in Bioinformatics journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-11T21:59:38.753+00:00 60 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1755843 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1755843 <![CDATA[Artificial intelligence in drug discovery from advanced molecular representation to pipeline applications]]> 2026-04-07T00:00:00Z Review Xiaoyu ZhouWeijing Tao https://www.frontiersin.org/articles/10.3389/fbinf.2026.1756081 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1756081 <![CDATA[Network pharmacology refined with non-ubiquity and decoy-controlled molecular docking reveals insights into Moringa oleifera phytochemicals targeting insulin resistance]]> 2026-03-10T00:00:00Z Original Research Armi Katrina Santos-EnriquezFabian M. DayritArmando Jerome de JesusNina Rosario L. Rojas https://www.frontiersin.org/articles/10.3389/fbinf.2026.1702572 https://www.frontiersin.org/articles/10.3389/fbinf.2026.1702572 <![CDATA[Unveiling the potential of apigenin and kaempferol against colon cancer: an integrated network pharmacology and docking approach]]> 2026-02-13T00:00:00Z Original Research Anushya SelvakumarPerpetual Ansel ChandranSai ShraddhaLoganathan Chandramani Priya DharshiniSarath PerumalRamanathan KaruppasamyAbul Kalam Azad Mandal https://www.frontiersin.org/articles/10.3389/fbinf.2025.1654326 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1654326 <![CDATA[Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches]]> 2025-12-10T00:00:00Z Original Research Mohamed Kalith Oli M.Jafar Ali Ibrahim Syed Masood https://www.frontiersin.org/articles/10.3389/fbinf.2025.1674179 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1674179 <![CDATA[Gene expression profile in colon cancer therapeutic resistance and its relationship with the tumor microenvironment]]> 2025-10-29T00:00:00Z Original Research Priscila Galvão DoriaGisele Vieira RochaVanessa Dybal BertoniRoberto de Souza Batista dos SantosMariana Araújo-PereiraClarissa Gurgel https://www.frontiersin.org/articles/10.3389/fbinf.2025.1666716 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1666716 <![CDATA[Drug repositioning pipeline integrating community analysis in drug-drug similarity networks and automated ATC community labeling to foster molecular docking analysis]]> 2025-10-23T00:00:00Z Original Research Daiana ColibăşanuVlad GrozaMaria Antonietta OcchiuzziFedora GrandeMihai UdrescuLucreția Udrescu https://www.frontiersin.org/articles/10.3389/fbinf.2025.1664576 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1664576 <![CDATA[Integrative machine learning and transcriptomic analysis identifies key molecular targets in MNPN-associated oral squamous cell carcinoma pathogenesis]]> 2025-09-25T00:00:00Z Original Research Xiangjun WangPanpan JinJuan XuJunyi LiMengzhen Ji https://www.frontiersin.org/articles/10.3389/fbinf.2025.1613136 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1613136 <![CDATA[Discovering biomarkers for chronic sinusitis with nasal polyps: a study integrating bioinformatics analysis and experimental validation of macrophage polarization and metabolism-related genes]]> 2025-09-15T00:00:00Z Original Research Juan ZhouHuan WangJin WangFuming Zhou 0.7 in both training and validation sets, showing strong diagnostic potential. A nomogram, built on these three biomarkers, exhibited superior diagnostic performance. Enrichment analysis suggested that these biomarkers might be implicated in immune pathways. Furthermore, all three biomarkers were found to be correlated with asthma. Selenium was identified as a co-target of ALOX5 and HMOX1, presenting potential therapeutic targets for CRSwNP. A total of 10 key miRNAs regulating these biomarkers were identified, and the upstream long non-coding RNAs of hsa-miR-642a-5p, including FOXC1 and NEAT1, were predicted. Additionally, the transcription factor FOXC1 was found to concurrently regulate all three biomarkers. RT-qPCR results validated that the expression levels of ALOX5, HMOX1, and PLA2G7 were significantly elevated in CRSwNP patients, corroborating the findings from bioinformatics analyses.ConclusionALOX5, HMOX1, and PLA2G7 were identified as biomarkers linked to macrophage polarization and metabolism in CRSwNP. These findings offer new insights for early prevention strategies and clinical drug development in CRSwNP.]]> https://www.frontiersin.org/articles/10.3389/fbinf.2025.1685992 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1685992 <![CDATA[Editorial: Networks and graphs in biological data: current methods, opportunities and challenges]]> 2025-09-02T00:00:00Z Editorial Derek L. ThompsonHsiang-Yun WuChristopher W. BartlettWilliam C. Ray https://www.frontiersin.org/articles/10.3389/fbinf.2025.1637479 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1637479 <![CDATA[The bacteriostatic regulation of luteolin from honeysuckle by protein network interaction]]> 2025-08-01T00:00:00Z Original Research Jianfeng ZhangMujun ChenDianzeng YangYanjie Jia https://www.frontiersin.org/articles/10.3389/fbinf.2025.1574797 https://www.frontiersin.org/articles/10.3389/fbinf.2025.1574797 <![CDATA[Bridging the gap between hepatocellular carcinoma management guidelines and personalised medicine: a Bayesian network study]]> 2025-05-29T00:00:00Z Original Research Yi-Chun WangDaniel BulteMichael Brady https://www.frontiersin.org/articles/10.3389/fbinf.2024.1419274 https://www.frontiersin.org/articles/10.3389/fbinf.2024.1419274 <![CDATA[Rhizobium etli CFN42 and Sinorhizobium meliloti 1021 bioinformatic transcriptional regulatory networks from culture and symbiosis]]> 2024-08-28T00:00:00Z Original Research Hermenegildo Taboada-CastroAlfredo José Hernández-ÁlvarezJuan Miguel Escorcia-RodríguezJulio Augusto Freyre-GonzálezEdgardo Galán-VásquezSergio Encarnación-Guevara https://www.frontiersin.org/articles/10.3389/fbinf.2024.1358374 https://www.frontiersin.org/articles/10.3389/fbinf.2024.1358374 <![CDATA[A layout framework for genome-wide multiple sequence alignment graphs]]> 2024-08-16T00:00:00Z Technology and Code Jeremias ScheberaDirk ZeckzerDaniel Wiegreffe https://www.frontiersin.org/articles/10.3389/fbinf.2024.1365200 https://www.frontiersin.org/articles/10.3389/fbinf.2024.1365200 <![CDATA[Network analysis of driver genes in human cancers]]> 2024-07-08T00:00:00Z Original Research Shruti S. PatilSteven A. RobertsAssefaw H. Gebremedhin https://www.frontiersin.org/articles/10.3389/fbinf.2023.1328262 https://www.frontiersin.org/articles/10.3389/fbinf.2023.1328262 <![CDATA[A breast cancer-specific combinational QSAR model development using machine learning and deep learning approaches]]> 2024-01-15T00:00:00Z Original Research Anush KarampuriShyam Perugu https://www.frontiersin.org/articles/10.3389/fbinf.2023.1214074 https://www.frontiersin.org/articles/10.3389/fbinf.2023.1214074 <![CDATA[Genome-scale metabolic models consistently predict in vitro characteristics of Corynebacterium striatum]]> 2023-10-23T00:00:00Z Original Research Famke BäuerleGwendolyn O. DöbelLaura CamusSimon HeilbronnerAndreas Dräger https://www.frontiersin.org/articles/10.3389/fbinf.2023.1276934 https://www.frontiersin.org/articles/10.3389/fbinf.2023.1276934 <![CDATA[Towards Chinese text and DNA shift encoding scheme based on biomass plasmid storage]]> 2023-10-12T00:00:00Z Original Research Xu YangLangwen LaiXiaoli QiangMing DengYuhao XieXiaolong ShiZheng Kou https://www.frontiersin.org/articles/10.3389/fbinf.2023.1254668 https://www.frontiersin.org/articles/10.3389/fbinf.2023.1254668 <![CDATA[Editorial: Expert Opinions in Network bioinformatics: 2022]]> 2023-07-19T00:00:00Z Editorial Paola Lecca https://www.frontiersin.org/articles/10.3389/fbinf.2023.1197310 https://www.frontiersin.org/articles/10.3389/fbinf.2023.1197310 <![CDATA[A guide for developing comprehensive systems biology maps of disease mechanisms: planning, construction and maintenance]]> 2023-06-22T00:00:00Z Methods Alexander MazeinMarcio Luis AcencioIrina BalaurAdrien RougnyDanielle WelterAnna NiarakisDiana Ramirez ArdilaUgur DogrusozPiotr GawronVenkata SatagopamWei GuAndreas KremerReinhard SchneiderMarek Ostaszewski https://www.frontiersin.org/articles/10.3389/fbinf.2023.1222711 https://www.frontiersin.org/articles/10.3389/fbinf.2023.1222711 <![CDATA[Editorial: Graph representation learning in biological network]]> 2023-06-09T00:00:00Z Editorial Swarup RoyPietro Hiram GuzziJugal Kalita