Frontiers in Biophysics | New and Recent Articles https://www.frontiersin.org/journals/biophysics RSS Feed for Frontiers in Biophysics | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-02T12:51:35.537+00:00 60 https://www.frontiersin.org/articles/10.3389/frbis.2026.1773451 https://www.frontiersin.org/articles/10.3389/frbis.2026.1773451 <![CDATA[Novel therapeutic approaches targeting biomechanical pathway alterations in bone diseases]]> 2026-04-01T00:00:00Z Review Malkiet KaurManju Nagpal https://www.frontiersin.org/articles/10.3389/frbis.2026.1795884 https://www.frontiersin.org/articles/10.3389/frbis.2026.1795884 <![CDATA[From the classical colloidal theory to biomolecular condensation: implications in health and disease]]> 2026-03-25T00:00:00Z Mini Review Noelia A. MelianAldana GomezMilagros B. AbatePamela L. ToledoMario R. ErmácoraDiego S. Vazquez https://www.frontiersin.org/articles/10.3389/frbis.2026.1804302 https://www.frontiersin.org/articles/10.3389/frbis.2026.1804302 <![CDATA[IDRs in Cross-Membrane Transport: Regulation of Ion Channels and Transporters, Mechanistic Studies Made Possible by NMR and Computational Methods]]> 2026-03-09T00:00:00Z Review Olga Vinogradova https://www.frontiersin.org/articles/10.3389/frbis.2025.1710099 https://www.frontiersin.org/articles/10.3389/frbis.2025.1710099 <![CDATA[Functional study of a novel SCN4A variant c.611C>T identified in a Japanese patient with myasthenia]]> 2026-01-08T00:00:00Z Original Research Natsuki KiraKosuke YoshidaSatoe TakahashiAyami YamanakaTakashi KimuraKazuaki HommaMasanori P. TakahashiTomoya Kubota T) located at the 3′ end of exon 4 in SCN4A. The analysis of the proband’s SCN4A mRNA showed that this variant causes an alanine-to-valine missense change at the amino acid position of 204 (p.A204V, 39%) and a disruption of the splicing of exons 4 and 5 leading to the production of truncated Nav1.4 variant protein (p.A204Vfs*94, 4%). We anticipated that the p.A204V missense change would impair Nav1.4 function; however, the ion channel activity and membrane targeting of p.A204V Nav1.4 were found to be wild-type (WT)-like. We also examined the cytotoxicities of the p.A204V and p.A204Vfs*94 variants; however, the cell lines heterologously overexpressing these Nav1.4 variant proteins did not induce cell death any more than the WT control. Although the loss or gain of anomalous ion channel function that is commonly suspected in channelopathies was ruled out in the present case, the precise mechanism of the pathogenic role of c.611C>T SCN4A remains to be elucidated.]]> https://www.frontiersin.org/articles/10.3389/frbis.2025.1693360 https://www.frontiersin.org/articles/10.3389/frbis.2025.1693360 <![CDATA[A blurry view of fuzzy objects: on the roles of low-resolution structural techniques in discovery and early characterization of intrinsically disordered proteins]]> 2025-12-03T00:00:00Z Review Vladimir N. Uversky https://www.frontiersin.org/articles/10.3389/frbis.2025.1693508 https://www.frontiersin.org/articles/10.3389/frbis.2025.1693508 <![CDATA[Vesicular and plasma membrane glutamate transporters]]> 2025-10-30T00:00:00Z Review Bart BorghansNatalia DmitrievaAleksandr NikiforovChristoph Fahlke https://www.frontiersin.org/articles/10.3389/frbis.2025.1681011 https://www.frontiersin.org/articles/10.3389/frbis.2025.1681011 <![CDATA[Proton channel Hv1 modulates microglial responses to neurological disorders]]> 2025-10-08T00:00:00Z Mini Review Maite StratmannCaterina GagliardiMelania Capasso https://www.frontiersin.org/articles/10.3389/frbis.2025.1652466 https://www.frontiersin.org/articles/10.3389/frbis.2025.1652466 <![CDATA[Identification of voltage-gated calcium currents in Helix (Cornu) serotonergic neurons, subcellular localization, and role in calcium dynamics and cellular firing of CaV2.1 and CaV2.2 subtypes]]> 2025-10-02T00:00:00Z Original Research María Laura Ríos-ReyesSilvia Calvo-CoreaOscar Brenes https://www.frontiersin.org/articles/10.3389/frbis.2025.1648934 https://www.frontiersin.org/articles/10.3389/frbis.2025.1648934 <![CDATA[From biophysics to cellular function: neural TELCs-membrane-anions capacitor transmembrane potential]]> 2025-09-18T00:00:00Z Review James Weifu Lee https://www.frontiersin.org/articles/10.3389/frbis.2025.1623880 https://www.frontiersin.org/articles/10.3389/frbis.2025.1623880 <![CDATA[Nanotribology of viruses reveals their adhesion strength and modality of motion on surfaces]]> 2025-08-07T00:00:00Z Original Research Charles AultClaudia SimonIrina B. TsvetkovaPedro J. De PabloBogdan Dragnea https://www.frontiersin.org/articles/10.3389/frbis.2025.1569091 https://www.frontiersin.org/articles/10.3389/frbis.2025.1569091 <![CDATA[Interaction studies between calmodulin and gating brake peptides from T-type channels]]> 2025-05-23T00:00:00Z Original Research Shivani YaduvanshiVeerendra Kumar https://www.frontiersin.org/articles/10.3389/frbis.2025.1543172 https://www.frontiersin.org/articles/10.3389/frbis.2025.1543172 <![CDATA[Activation of transient receptor vanilloid 4 increases connexin hemichannel activity in porcine ciliary nonpigmented epithelium]]> 2025-04-25T00:00:00Z Original Research J. F. Ek-VitorinM. ShahidullahN. A. Delamere https://www.frontiersin.org/articles/10.3389/frbis.2025.1560824 https://www.frontiersin.org/articles/10.3389/frbis.2025.1560824 <![CDATA[Decoding TBCK: from bioinformatic insights of domain architecture to disease implications]]> 2025-04-04T00:00:00Z Review Emma M. CagwinCaitlin M. PadgettYvonne LinWen Zhu https://www.frontiersin.org/articles/10.3389/frbis.2024.1479898 https://www.frontiersin.org/articles/10.3389/frbis.2024.1479898 <![CDATA[Functional dynamics of human ubiquitin C-terminal hydrolases]]> 2024-11-06T00:00:00Z Review Sarita PuriShang-Te Danny Hsu https://www.frontiersin.org/articles/10.3389/frbis.2024.1406868 https://www.frontiersin.org/articles/10.3389/frbis.2024.1406868 <![CDATA[Unlocking the brain’s zinc code: implications for cognitive function and disease]]> 2024-06-12T00:00:00Z Review Soheila SabouriMarzieh RostamiradRobert E. Dempski https://www.frontiersin.org/articles/10.3389/frbis.2024.1342506 https://www.frontiersin.org/articles/10.3389/frbis.2024.1342506 <![CDATA[Chaperone regulation of biomolecular condensates]]> 2024-05-07T00:00:00Z Review Jared A. M. BardD. Allan Drummond https://www.frontiersin.org/articles/10.3389/frbis.2024.1367511 https://www.frontiersin.org/articles/10.3389/frbis.2024.1367511 <![CDATA[Utilizing surface plasmon resonance as a novel method for monitoring in-vitro P-glycoprotein efflux]]> 2024-03-08T00:00:00Z Original Research Phuong H. NguyenShuolin CuiAmanda M. KozarichAlex RautioArthur G. RobertsMay P. Xiong https://www.frontiersin.org/articles/10.3389/frbis.2024.1359979 https://www.frontiersin.org/articles/10.3389/frbis.2024.1359979 <![CDATA[Symmetry of a partially-ligated state maintained by dynamics in a negatively cooperative system]]> 2024-02-23T00:00:00Z Original Research Rebecca StrawnParvathi S. MurthyRüdiger H. EttrichIstván PelczerJannette Carey https://www.frontiersin.org/articles/10.3389/frbis.2023.1334804 https://www.frontiersin.org/articles/10.3389/frbis.2023.1334804 <![CDATA[Expression, purification and folding of native like mitochondrial carrier proteins in lipid membranes]]> 2024-01-08T00:00:00Z Original Research Marzieh TabefamMatthew D. SmithMasoud Jelokhani-Niaraki https://www.frontiersin.org/articles/10.3389/frbis.2023.1338019 https://www.frontiersin.org/articles/10.3389/frbis.2023.1338019 <![CDATA[Archaea membranes in response to extreme acidic environments]]> 2024-01-04T00:00:00Z Mini Review Parkson Lee-Gau Chong