AUTHOR=Weidener Lukas , Spreckelsen Cord TITLE=Decentralized science (DeSci): definition, shared values, and guiding principles JOURNAL=Frontiers in Blockchain VOLUME=Volume 7 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/blockchain/articles/10.3389/fbloc.2024.1375763 DOI=10.3389/fbloc.2024.1375763 ISSN=2624-7852 ABSTRACT=Rapid advancements in Distributed Ledger Technology (DLT), including blockchain, are foundational to a new era of digital innovation. This innovation has catalyzed the emergence of 'Decentralized Science (DeSci),' a new concept and movement that aims to address the challenges of modern science. Given the novelty of the field of DeSci, this study aims to provide a comprehensive definition of the term as well as explore and conceptualize shared values and guiding principles inherent to DeSci. In line with the objectives of this study, an exploratory literature review was conducted to identify and synthesize the scholarly and secondary literature. The search and selection process included six databases (PubMed, Google Scholar, Web of Science, IEEE Xplore, arXiv, and Social Science Research Network), and the search period was limited to the last 15 years, from 2008 to 2023. Owing to the novelty of the concept and movement of DeSci, the exploratory literature review was supplemented by an anonymous online-based expert survey using a combination of single-choice and open-ended questions. The experts were selected based on predefined inclusion criteria, in association with their activities in the field of DeSci. Seven studies were selected for evaluation as part of the search and selection process to identify relevant scholarly literature. Following the review of secondary literature, additional 24 sources of information could be included in the analysis. In the expert survey, 39 valid datasets were collected and analyzed. Following the synthesis of the results of the exploratory literature review and expert survey, a comprehensive definition of the term 'Decentralized Science' (DeSci) was formulated to reflect recurring themes. As no publications that explicitly discussed or addressed the values or principles of DeSci in the exploratory literature review could be identified, a set of shared values and guiding principles for DeSci were defined based on the results of the expert survey. While this study proposes a comprehensive definition of DeSci as well as a set of shared values and guiding principles, the results of this study highlight the importance for future research.