AUTHOR=Haase Tina , Börnigen Daniela , Müller Christian , Zeller Tanja 

TITLE=Systems Medicine as an Emerging Tool for Cardiovascular Genetics

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 3 - 2016

YEAR=2016

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2016.00027

DOI=10.3389/fcvm.2016.00027

ISSN=2297-055X

ABSTRACT=Cardiovascular disease is a major contributor to morbidity and mortality worldwide. However, the pathogenesis of cardiovascular disease is complex and remains elusive. Within the last years, systems medicine has emerged as a novel tool to study the complex genetic, molecular and physiological interactions leading to diseases. In this review, we provide an overview about the current approaches for systems medicine in cardiovascular disease. They include bioinformatical as well as experimental tools such as cell and animal models, omics technologies, network and pathway analyses. Additionally, we discuss challenges and current literature examples where systems medicine has been successfully applied for the study of cardiovascular disease.