AUTHOR=Gasior Tomasz , Gavazzoni Mara , Taramasso Maurizio , Zuber Michel , Maisano Francesco TITLE=Direct Percutaneous Mitral Annuloplasty in Patients With Functional Mitral Regurgitation: When and How JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=Volume 6 - 2019 YEAR=2019 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2019.00152 DOI=10.3389/fcvm.2019.00152 ISSN=2297-055X ABSTRACT=Mitral regurgitation (MR) is a frequent valvular disease among patients deemed too high risk for surgery. Echocardiography along with CT is the primary diagnostic tool for MR and offers a comprehensive 3D assessment in patient selection and screening for the optimal treatment method. The direct percutaneous mitral annuloplasty addresses the underlying mechanisms of functional mitral regurgitation with a less invasive, catheter-based approach. The described here devices proved a satisfactory safety profile, provided significant MR reduction in most of the patients, and were associated with a significant improvement of symptoms. Although long term outcome assessment is needed to support these early reports, the percutaneous mitral annuloplasty is likely to set a new standard of treatment in the forthcoming future.