AUTHOR=Wang Youmeng , Fernandes Branco Roberto , Fietzeck Andrea , Penzel Thomas , Schöbel Christoph 

TITLE=Feasibility of Transcatheter Caval Valve Implantation to Improve Sleep-Disordered Breathing in Patients With Severe Tricuspid Regurgitation—A Pilot Study

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.673164

DOI=10.3389/fcvm.2021.673164

ISSN=2297-055X

ABSTRACT=Transcatheter caval valve implantation (CAVI) has been evaluated as a treatment option for inoperable patients with severe symptomatic tricuspid regurgitation (TR). We studied the effect of CAVI on sleep disorder breathing (SDB) in patients with right heart failure and TR. Twenty right heart failure patients with severe symptomatic TR underwent portable monitoring of SDB (ApneaLink), echocardiography, cardiopulmonary exercise (CPET) and laboratory testing were enrolled. This was a single-center, non-blinded, randomized controlled study. Repeated ANOVA measures was used for data analysis. There were no significant changes in sleep variables, echocardiographic parameters, laboratory results, lung function and CPET after 1 month treatment in all groups. In conclusion, we are not able to find significant impact of CAVI on SDB in patients with severe symptomatic TR in the short-term follow. The findings reveal a feasible clinical model for further investigation of the mechanisms that underlie the association of cardiac disorders and SDB.