AUTHOR=Wang Jie , Tang Manyun , Long Yunxiang , Song Jingzhuo , Chen Limei , Wang Mengchang , Li Yongxin , Sun Chaofeng , Yan Yang 

TITLE=Prognostic Potential of Heart Rate and Hypertension in Multiple Myeloma Patients

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.681484

DOI=10.3389/fcvm.2021.681484

ISSN=2297-055X

ABSTRACT=Background: The prognosis of patients with multiple myeloma (MM) is variable and partly depends on their cardiovascular status. The presence of arrhythmias can lead to worse outcomes. Therefore, the aim of the present study was to evaluate the prognostic potential of heart rate (HR) and hypertension in MM patients.
Methods: This study retrospectively enrolled patients with MM between January 1st, 2010, and December 31st, 2018, at the First Affiliated Hospital of Xi’an Jiao Tong University. Univariate and multivariate Cox proportional hazards models were developed to evaluate the relationship between HR, hypertension and all-cause mortality.
Results: A total of 386 patients were included. The mean HR was 83.8 ± 23.1 beats per minute (bpm). Patients with HR > 100 bpm had a higher all-cause mortality (79.4%, 50/63) than those with 60 ≤ HR ≤ 100 bpm (39.9%, 110/276) and < 60 bpm (19.1%, 9/47) (P < 0.001). Subgroup analysis based on the International Staging System and sex revealed similar relationships (P < 0.01). When stratified by age, patients with HR > 100 bpm had higher all-cause mortality than the those with a lower HR when age was < 65 years or 65-75 years (P < 0.001) but not >75 years. The proportion of patients with hypertension was 54.7% (211/386). However, hypertension was not an independent risk factor for all-cause mortality in MM patients. MM patients with HR > 100 bpm had the highest all-cause mortality.
Conclusions: The prognostic potential of HR may be powerful in aiding risk stratification and promoting the management of these patients.