AUTHOR=Tornvall Per , Pettersson Hans Järnbert 

TITLE=Reproductive History in Takotsubo Syndrome, A Register-Based Cohort Study

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.692122

DOI=10.3389/fcvm.2021.692122

ISSN=2297-055X

ABSTRACT=Background: Takotsubo syndrome (TS) is a recently recognized serious heart condition that mainly affects women. Despite that 80-90 % of the patients are women, few studies have focused on sex-specific characteristics such as female sex hormones and reproductive history. The aim of the study was to compare reproductive history in patients with TS with controls.
Methods: This register-based cohort study compared reproductive history and off-spring birth characteristics between 158 TS patients without coronary artery stenoses and 236 age- and sex-matched controls (C) with coronary artery stenoses because of acute coronary syndrome (ACS-C), respectively 285 without coronary artery stenoses with chest pain (CP-C).
Results: There were no differences in pregnancy complications between TS and CP-C. Gestational length did not differ, but infants born to TS patients had lower birth weight for gestational age than CP-C with an odds ratio of 1.7 (95% confidence interval 1.2-2.5) for infants born small.
Conclusion: Information about reproductive history in women, in particular birth characteristics, can potentially be a risk marker for future TS.