AUTHOR=Boeder Niklas F. , Dörr Oliver , Koepp Tim , Blachutzik Florian , Achenbach Stephan , Elsässer Albrecht , Hamm Christian W. , Nef Holger M. 

TITLE=Acute Mechanical Performance of Magmaris vs. DESolve Bioresorbable Scaffolds in a Real-World Scenario

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.696287

DOI=10.3389/fcvm.2021.696287

ISSN=2297-055X

ABSTRACT=Background: After the bioresorbable PLLA-based vascular scaffold (Absorb BVS) was taken from the market due to its high adverse event rates, a magnesium-based scaffold (Magmaris) was introduced.
Objective: To compare the acute performance of the sirolimus-eluting magnesium alloy Magmaris scaffold with that of the novolimus-eluting PLLA-based DESolve scaffold in terms of appropriate scaffold deployment using optical coherence tomography (OCT).
Methods and Results: Data from the final OCT pullback of 98 patients were included (19 Magmaris, 79 DESolve) and analysed at 1-mm intervals. The following indices were calculated: mean and minimal area, residual area stenosis, incomplete strut apposition, tissue prolapse, eccentricity index, symmetry index, strut fracture, and edge dissection. OCT showed a minimum lumen area for Magmaris vs. DESolve of 6.6±1.6 vs. 6.0±1.9 (p=0.06). Scaffolds with residual aortic stenosis >20% were predominantly seen in the DESolve group (15.8% vs. 46.8%; p=0.01). The mean eccentricity index did differ significantly (0.74±0.06 vs.0.63±0.09; p<0.001). No fractures were observed for Magmaris scaffolds, but 15.2% were documented for DESolve BRS (p<0.001). Incomplete scaffold apposition area was significantly higher in the DESolve group (0.01±0.02 mm2 vs. 1.05±2.32 mm2; p<0.001).
Conclusion: This is the first study to compare the acute mechanical performance between Magmaris and DESolve in a real-world setting. The acute mechanical performance of Magmaris BRS seems to be superior to that of DESolve BRS, whereas OCT showed a good acute mechanical performance for both BRS in terms of generally accepted imaging criteria.