AUTHOR=Xu Bin , Liu Lu , Abdu Fuad A. , Yin Guoqing , Mohammed Abdul-Quddus , Xu Siling , Lv Xian , Fan Rui , Feng Cailin , Shi Tingting , Zhang Wen , Xu Yawei , Cai Haidong , Yu Fei , Che Wenliang 

TITLE=Prognostic Value of Diastolic Dysfunction Derived From D-SPECT in Coronary Artery Disease Patients With Normal Ejection Fraction

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.700027

DOI=10.3389/fcvm.2021.700027

ISSN=2297-055X

ABSTRACT=Diastolic dysfunction (DD) with normal systolic function has been elucidated to be associated with heart failure and worse prognosis. The recently introduced SPECT with dedicated cardiac cadmium–zinc–telluride (CZT) cameras (D-SPECT) is a novel method to quantitate left ventricular functional parameters. We aimed to evaluate the prognostic value of DD derived from D-SPECT in coronary artery disease (CAD) patients with normal ejection fraction. All CAD patients who underwent D-SPECT and invasive coronary angiography within 3 months were considered. DD was defined as peak filling rate (PFR) < 2.1 EDV (End diastolic volume, mL)/s according to the D-SPECT results. Patients were divided into three groups: group 1 (n=226)—normal PFR; group 2 (n=67)—ischemia related DD (abnormal stress PFR and normal rest PFR); group 3 (n=106)—rest DD (abnormal rest PFR). The primary clinical endpoint of the present study was a composite of heart failure events (HFE). A total of 399 consecutive CAD patients with normal systolic function undergoing stress D-SPECT were analyzed. The incidence of HFE among the three groups were 4.0%, 7.5% and 11.3%, respectively. Cox regression analysis showed the multivariate predictors of HFE were rest PFR, diabetes mellitus, obesity and old age.DD derived from D-SPECT in CAD patients with normal ejection fraction is predictive of HFE.