AUTHOR=Li Junyi , Zhou Li , Ouyang Xinping , He Pingping 

TITLE=Transcription Factor-7-Like-2 (TCF7L2) in Atherosclerosis: A Potential Biomarker and Therapeutic Target

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.701279

DOI=10.3389/fcvm.2021.701279

ISSN=2297-055X

ABSTRACT=Transcription factor-7-like-2 (TCF7L2), a vital member of T-cell factor/lymphoid enhancer factor (TCF/LEF), plays a manifold role in human normal physiological and pathological processes. TCF7L2 shows multiple anti-atherosclerosis effect by activating certain molecular mechanisms, including regulation of metabolism balance, macrophage polarization, neointimal hyperplasia. A Single-nucleotide substitutions (SNP) of TCF7L2-rs7903146, a genetic high-risk factor for type 2 diabetes, is susceptible to cardiovascular disease as a link between metabolism disorder and atherosclerosis. In this review, we summarize the anti-atherosclerosis effect and novel mechanisms of TCF7L2 to elaborate a potential anti-atherosclerosis biomarker and provide a therapeutic target for cardiovascular diseases.