AUTHOR=Hu Huilin , Chen Yunqing , Jing Lele , Zhai Changlin , Shen Liang 

TITLE=The Link Between Ferroptosis and Cardiovascular Diseases: A Novel Target for Treatment

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.710963

DOI=10.3389/fcvm.2021.710963

ISSN=2297-055X

ABSTRACT=Ferroptosis is an iron-dependent cell death, which is characterized by iron overload and lipid reactive oxygen species (ROS) accumulation. Ferroptosis is morphologically, biochemically, and genetically distinct from apoptosis, necrosis, autophagy and other forms of cell death. Ferroptosis is regulated by a variety of factors and controlled by several mechanisms, including mitochondrial activity and metabolism of iron, lipid and amino acids. Accumulating evidence shows that ferroptosis is closely associated with the pathophysiological processes of a variety of cardiovascular diseases (CVDs), including cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, heart failure and atherosclerosis. This review summarizes the current status of ferroptosis and discusses ferroptosis as a potential therapeutic target for CVDs.