AUTHOR=Zhao Xiaoqian , Liu Yuan , Zhang Jinping , Fu Shihui , Song Chengyun , Bai Yongyi , Luo Leiming 

TITLE=Acute Lower Respiratory Tract Infection Increased the Risk of Cardiovascular Events and All-Cause Mortality in Elderly Patients With Stable Coronary Artery Disease

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.711264

DOI=10.3389/fcvm.2021.711264

ISSN=2297-055X

ABSTRACT=Objective To determine the risk factors and the prognosis of acute cardiovascular events in the elderly with stable coronary artery disease (sCAD) within 90 days after an acute lower respiratory tract infection (ALRTI). 
Methods Observational analysis of a prospective cohort of the elderly with sCAD during 90 days after ALRTI. A multiple logistic regression analysis was performed to identify predictors for acute cardiovascular events and all-cause mortality.
Results This study comprised 426 patients of sCAD with a median age 88 (84–91) years. Among them, 257 patients who were hospitalized for a ALRTI were regarded as subjects (infection group), meanwhile, 169 patients who did not suffered from ALRTI were chose as controls (none-infection group). Compared with the none-infection group, the infection group had a higher incidence of acute cardiovascular events (31.9% vs 13.6%, p<0.001) and a higher all-cause mortality (13.2% vs 1.8%, p<0.001) during 90- day follow-up. In addition, in the infection group, the incidence of cardiovascular events was also higher than those in none-infection group during 7-day and 30-day follow-up (10.9% vs 2.4%, p=0.001; 20.6% vs 6.5%, p<0.001). The same trends as all-cause mortality during 7days and 30 days (1.2% vs 0%, p=0.028; 3.9% vs 0.6%, p=0.021) were observed in two groups. Furthermore, multiple regression analysis found that ALRTI was independently associated with increased risk of cardiovascular events and all-cause mortality in those elderly patients with sCAD. 
Conclusion In elderly patients with stable coronary artery disease, ALRTI was an independent predictor both for cardiovascular events and all-cause mortality.