AUTHOR=Salybekov Amankeldi A. , Kunikeyev Aidyn D. , Kobayashi Shuzo , Asahara Takayuki 

TITLE=Latest Advances in Endothelial Progenitor Cell-Derived Extracellular Vesicles Translation to the Clinic

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.734562

DOI=10.3389/fcvm.2021.734562

ISSN=2297-055X

ABSTRACT=Almost all nucleated cells secrete extracellular vesicles (EVs) with a heterogeneous spheroid pattern or round particles ranging from 30 to 200nm. Recent preclinical and clinical studies have shown that Endothelial progenitor cell-derived extracellular vesicles (EPC-EVs) have a beneficial therapeutic effect for various diseases, including cardiovascular diseases (CVD), kidneys, and lung (Fig 1). Moreover, some animal studies showed that EPC-EVs selectively accumulate in the injury site with a specific mechanism of binding along with the superior angiogenic and restorative effect of EPC-EVs than the ancestor. This review article highlights current advances in EPC-EVs biogenesis, route of delivery, long-term storage methods, and favorable effects such as anti-inflammatory, angiogenic, and tissue protection on various diseases. Finally, we review the possibility of therapeutic application of EPC-EVs into the clinic.