AUTHOR=Guo Li-Ling , Zhu Li-Yuan , Xu Jin , Xie Ying-Ying , Xiang Qun-Yan , Jiang Zhe-Yi , Tan Yang-Rong , Liu Ling 

TITLE=Determination of the Optimal Cutoff Value of Triglyceride That Corresponds to Fasting Levels in Chinese Subjects With Marked Hypertriglyceridemia

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.736059

DOI=10.3389/fcvm.2021.736059

ISSN=2297-055X

ABSTRACT=The level of triglyceride (TG) ≥ 2.3mmol/L is suggestive of marked hypertriglyceridemia (HTG), and requires treatment with a triglyceride-lowering agent in high-risk and very-high-risk patients as recommended by the guidelines. However, the optimal cut-off value required to diagnose non-fasting HTG that corresponds to the fasting goal level of 2.3 mmol/L in Chinese subjects is unknown. This study enrolled 602 cardiology inpatients. Blood lipid levels, including calculated non-high-density lipoprotein cholesterol (non-HDL-C) and remnant cholesterol (RC), were measured at 0, 2, and 4 h after a daily Chinese breakfast. Of these, 482 inpatients had TG levels of < 2.3mmol/L (CON group) and 120 inpatients had TG levels of ≥ 2.3mmol/L (HTG group). Receiver operating characteristic (ROC) curve analysis was used to determine the cut-off values for postprandial HTG that corresponded to a target fasting level of 2.3 mmol/L. Marked hypertriglyceridemia (≥ 2.3mmol/L) was found in 120 (19.9%) patients in this study population. The levels of non-fasting TG and RC increased significantly in both groups and reached the peak at 4 h after a daily meal, especially in HTG group (P < 0.05). The optimal cut-off value of TG at 4h, which corresponds to fasting TG of ≥ 2.3 mmol/L, that can be used to predict HTG, was 2.66 mmol/L. According to the new non-fasting cut-off value, the incidence of non-fasting HTG is close to its fasting level. In summary, this is the first study to determine the non-fasting cut-off value that corresponds to a fasting TG of ≥ 2.3 mmol/L in Chinese patients. Additionally, 2.66 mmol/l at 4 h after a daily meal could be an appropriate cut-off value that can be used to detect non-fasting marked HTG in Chinese subjects.