AUTHOR=Ning Feifei , Tang Manyun , Wang Mengjie , Muhlestein Joseph B. , Day John D. , Li Guoliang , Yan Yang TITLE=Case Report: Extrinsic Compression of the Left Main Coronary Artery by a Giant Sinus of Valsalva Aneurysm JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=Volume 8 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.753154 DOI=10.3389/fcvm.2021.753154 ISSN=2297-055X ABSTRACT=Sinus of Valsalva aneurysm (SoVA) is an uncommon clinical entity, which is present in roughly 0.09% of the general population. The cause can be either acquired or congenital. Clinically SoVA of unruptured status are hardly captured even diagnosed due to atypical clinical presentations. Here we present a rare case of exertional angina pectoris and recurrent syncope due to an extrinsically compressed left coronary artery by a gaint SoVA in a 50-year-old female patient, which was successfully repaired by surgical exclusion and was still doing well after two years of follow-up. In a word, the clinical presentations, precise imaging and anatomy proof and effective surgical treatment make the case extremely rare and interesting.