AUTHOR=Mandry Damien , Girerd Nicolas , Lamiral Zohra , Huttin Olivier , Filippetti Laura , Micard Emilien , Ncho Mottoh Marie-Paule Bernadette , Böhme Philip , Chemla Denis , Zannad Faïez , Rossignol Patrick , Marie Pierre-Yves 

TITLE=Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.771022

DOI=10.3389/fcvm.2021.771022

ISSN=2297-055X

ABSTRACT=Introduction: This study aims to assess the changes in cardiovascular remodeling attributable to bodyweight gain in a middle-aged abdominal obesity cohort. A remodeling worsening might explain the increase in cardiovascular risk associated with a dynamic of weight gain.
Methods: Seventy-five middle-aged subjects (56±5 years, 38 women) with abdominal obesity and no known cardiovascular disease underwent MRI-based examinations at baseline and at a 6.1±1.2-year follow-up to monitor cardiovascular remodeling and hemodynamic variables, most notably the effective arterial elastance (Ea). Ea is a proxy of the arterial load that must be overcome during left ventricular (LV) ejection, with increased EA resulting in concentric LV remodeling. 
Results: Sixteen obese subjects had significant weight gain (> 7%) during follow-up (WG+), whereas the 59 other individuals did not (WG-). WG+ and WG- exhibited significant differences in the baseline to follow-up evolutions of several hemodynamic parameters, notably diastolic and mean blood pressures (for mean blood pressure, WG+: +9.3±10.9 mmHg vs. WG-: +1.7±11.8 mmHg, p=0.022), heart rate (WG+: +0.6±9.4 min-1 vs. -8.9±11.5 min-1, p=0.003), LV concentric remodeling index (WG: +0.08±0.16 g.mL-1 vs. WG-: -0.02±0.13 g.mL-1, p=0.018) and Ea (WG+: +0.20±0.28 mL.mmHg-1 vs. WG-: +0.01±0.30 mL.mmHg-1, p=0.021). The evolution of the LV concentric remodeling index and Ea were also strongly correlated in the overall obese population (p<0.001, R2=0.31).
Conclusions: A weight gain dynamic is accompanied by increases in arterial load and load-related concentric LV remodeling in an isolated abdominal obesity cohort. This remodeling could have a significant impact on cardiovascular risk.