AUTHOR=Xin Yanguo , Zhang Xiaodong , Li Jingye , Gao Hui , Li Jiayu , Li Junli , Hu Wenyu , Li Hongwei 

TITLE=New Insights Into the Role of Mitochondria Quality Control in Ischemic Heart Disease

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.774619

DOI=10.3389/fcvm.2021.774619

ISSN=2297-055X

ABSTRACT=IHD is a significant cause of mortality and morbidity worldwide. In acute phase, it’s demonstrated as myocardial infarction and ischemia-reperfusion injury, while in chronic stage, ischemic heart is mainly characterized by adverse myocardial remodelling. Although interventions such as thrombolysis and percutaneous coronary intervention could reduce the death risk of these patients, the underlying cellular and molecular mechanisms need more explorations. Mitochondria are crucial to maintain the physiological function of the heart. During IHD, mitochondrial dysfunction results in the pathogenesis of ischemia heart disease. Ischemia drives mitochondrial damage not only due to energy deprivation, but also to other aspects such as mitochondrial dynamics, mitochondria-related inflammation etc. Given the critical role of mitochondrial quality control in the pathological process of ischemia heart disease, in this review, we will summarize the efforts in targeting mitochondria (such as mitophagy, mtROS and mitochondria-related inflammation) on IHD. In addition, we will briefly revisit the emerging therapeutic targets in this field.