AUTHOR=Li Jiehui , Wang Shuiyun , Sun Hansong , Xu Jianping , Dong Chao , Song Min , Yu Qibin TITLE=Clinical and Surgical Evaluations of Reoperation After Mechanical Mitral Valve Replacement Due to Different Etiologies JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=Volume 8 - 2021 YEAR=2022 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.778750 DOI=10.3389/fcvm.2021.778750 ISSN=2297-055X ABSTRACT=Background: This study aimed to evaluate the clinical and surgical characteristics of patients who required reoperation after mechanical mitral valve replacement (MVR). Methods: We retrospectively identified 204 consecutive patients who underwent reoperation after mechanical MVR between 2009 and 2018. Patients were categorized according the reason for reoperation (perivalvular leakage, thrombus formation, or pannus formation). The patients’ medical and surgical records were studied carefully and the rates of in-hospital complications were calculated. Results: The mean age was 51±12 years and 44% of the patients were male. The reasons for reoperation were perivalvular leakage (117 patients), thrombus formation (35 patients), and pannus formation (52 patients). The most common positions for perivalvular leakage were at the 6–10 o’clock positions (proportions of ≥25% for each hour position). Most patients had an interval of >10 years between the original MVR and reoperation. The most common reoperation procedure was re-do MVR (157 patients), and 155 of these patients underwent concomitant cardiac procedures. There were 10 in-hospital deaths and 32 patients experienced complications, which included in-hospital death, bleeding that required reoperation, continuous renal replacement therapy, intra-aortic balloon pump use, tracheotomy, stroke, ventilator use for ≥96 h, and an intensive care unit stay of ≥7 days. Atrial fibrillation before secondary operation was a risk factor for complications (odds ratio: 2.97, 95% confidence interval: 1.15–7.63, p=0.024). Conclusions: Perivalvular leakage was the most common reason for reoperation after mechanical MVR.