AUTHOR=Sazzad Faizus , Hon Jimmy Kim Fatt , Ramanathan Kollengode , Nah Jie Hui , Ong Zhi Xian , Ti Lian Kah , Foo Roger , Tay Edgar , Kofidis Theo 

TITLE=Design Variation, Implantation, and Outcome of Transcatheter Mitral Valve Prosthesis: A Comprehensive Review

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.782278

DOI=10.3389/fcvm.2021.782278

ISSN=2297-055X

ABSTRACT=Transcatheter mitral valve prosthesis is ideally suited for patients with inoperable mitral etiology. Transcatheter mitral valve replacement (TMVR) procedure has closely followed the evolution of  transcatheter aortic procedures. There are considerable design variations amongst the limited TMVR prostheses currently available and the implantation profile of the devices are notably different. This comprehensive review will provide a current overview of the current clinically tried TMVR devices, with a focused outcome analysis. In addition, we have discussed the various design characteristics of TMVR and its associated failure mode, implantation technology, delivery methods, first-in-man trials and pivotal trial summary for synthesis of current evidence.