AUTHOR=Guo Zhiye , Du Xiaolong , Zhang Yihua , Su Chunwan , Ran Feng , Lu Qiulun 

TITLE=Diosmin Alleviates Venous Injury and Muscle Damage in a Mouse Model of Iliac Vein Stenosis

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.785554

DOI=10.3389/fcvm.2021.785554

ISSN=2297-055X

ABSTRACT=Iliac vein stenosis (IVS) occurs commonly in affluent countries and are a socioeconomic burden. However, the mechanism underlying venous pathophysiology remains unclear. Mouse model of iliac vein stenosis was generated by iliac ligature, and then treated with micronized diosmin. In this pathophysiological condition, venous permeability is increased, with the elevated levels of inflammatory response and impaired surrounding muscles. Micronized diosmin was in a dose-dependent way to repress the inflammatory stress and maintain the venous integrity. These results indicate that micronized diosmin is an effective therapeutic drug for venous permeability and surrounding tissues.