AUTHOR=Basavaraju Preethi , Balasubramani Rubadevi , Kathiresan Divya Sri , Devaraj Ilakkiyapavai , Babu Kavipriya , Alagarsamy Vasanthakumar , Puthamohan Vinayaga Moorthi 

TITLE=Genetic Regulatory Networks of Apolipoproteins and Associated Medical Risks

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 8 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.788852

DOI=10.3389/fcvm.2021.788852

ISSN=2297-055X

ABSTRACT=Apolipoproteins are the lipoprotein family proteins that play key roles in transporting lipoproteins all over the body. There are nearly more than twenty members reported in the apolipoprotein family, among which the A, B, C, E and L play major roles in contributing genetic risks to several disorders. Amongst these genetic risks the Single nucleotide polymorphisms (SNPs), involving the variation of single nucleotide base pairs, and their contributing polymorphisms play crucial roles in the apolipoprotein family and its concordant disease heterogeneity that have predominantly recurred through the years. In this review we have contributed a handful of information on such genetic polymorphisms that include APOE, ApoA1/B ratio and A1/C3/A4/A5 gene cluster based population genetic studies carried throughout the world, to elaborately discuss the effects of various genetic polymorphisms in imparting various medical conditions including cardiovascular, stroke, Alzheimer’s disease, Diabetes, Vascular complications and other associated risks.