AUTHOR=Lowis Christiana , Ramara Winaya Aurellia , Kumari Puja , Rivera Cristobal F. , Vlahos John , Hermantara Rio , Pratama Muhammad Yogi , Ramkhelawon Bhama 

TITLE=Mechanosignals in abdominal aortic aneurysms

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 9 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.1021934

DOI=10.3389/fcvm.2022.1021934

ISSN=2297-055X

ABSTRACT=Cumulative evidence has shown that mechanical and frictional forces exert distinct effects in the multi-cellular aortic layers and play a significant role in the development of abdominal aortic aneurysm (AAA). These mechanical cues collectively trigger signalling cascades relying on mechanosensory cellular hubs that regulate vascular remodelling programs leading to the exaggerated degradation of the extracellular matrix (ECM), culminating in lethal aortic rupture. In this review, we provide an update and summarize the current understanding of the mechanotransduction networks in different cell types during AAA development. We focus on different mechanosensors and stressors that accumulate in the AAA sac and the mechanotransduction cascades that contribute to inflammation, oxidative stress, remodeling, and ECM degradation. We provide perspectives on manipulating this mechano-machinery as a new direction for future research toward disease prediction and non-interventional therapeutic strategies in AAA.