AUTHOR=Zhao Yuhao , Zhang Yeping , Guo Zongsheng , Ma Zheng , Liu Ye , Han Chunming , Yang Xinchun , Zhao Lei 

TITLE=Elevated Plasma Thymic Stromal Lymphopoietin After Acute Myocardial Infarction

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.685677

DOI=10.3389/fcvm.2022.685677

ISSN=2297-055X

ABSTRACT=Abstract
Background: Thymic stromal lymphopoietin (TSLP), a distant paralog of the cytokine IL-7, has been shown to be associated with atherosclerosis, but there is currently no evidence on the role of plasma TSLP level after acute myocardial infarction (AMI) in clinical practice. Therefore, we aimed to evaluate the relationship between TSLP concentration at admission and the risk of major adverse cardiovascular events (MACE) in patients with AMI.

Methods: A total of 175 AMI patients and 145 unstable angina (UA) controls were recruited in the present study. Clinical parameters were collected, and MACE was recorded during hospitalization and follow-up after discharge.

Results: The median value (25, 75 percentiles) of TSLP concentrations in the AMI group was higher than that in the UA group [11.18 (IQR 8.14-15.22) vs. 8.56 (IQR 5.26-11.94) pg/ml, p＜0.001, respectively]. Multivariate linear regression analyses indicated that D-dimer (standardized β=0.148, p=0.031) was an independent factor for TSLP. Based on the median value of TSLP concentrations in the AMI cohort, we divided the patients into the high level group (TSLP level ≥11.18 pg/ml, N=91) and the low level group (TSLP＜11.18 pg/ml, N=84). After a median follow-up of 14 months, Kaplan-Meier survival analysis revealed that MACE-free survival was not significantly different between the two groups (p=0.648). In a receiver operating characteristic curve analysis, using a cutoff value of 9.235 pg/ml, the area under the curve for TSLP as a predictor of AMI was 0.674. 

Conclusions: Plasma TSLP levels were elevated in patients with AMI than those in UA. The high TSLP concentration was associated with MACE after AMI.