AUTHOR=Tan Yangrong , Lin Qiuzhen , Xu Jin , Zhu Liyuan , Guo Liling , Xie Yingying , Du Xiao , Zhang Shilan , Wen Tie , Liu Ling 

TITLE=Non-fasting Changes in Blood Lipids After Three Daily Meals Within a Day in Chinese Inpatients With Cardiovascular Diseases

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.799300

DOI=10.3389/fcvm.2022.799300

ISSN=2297-055X

ABSTRACT=Background: Non-fasting lipid test has been recommended in clinical practice. However, the change in blood lipids in Chinese patients with cardiovascular diseases after three daily meals was never reported yet. 
Methods: Seventy-seven (48 males and 29 females) Chinese inpatients with cardiovascular diseases were enrolled in this study. After an overnight fast (≥12h), all subjects took three daily meals within a day according to their own habits. Blood lipid levels were measured or calculated in the fasting state and at 4 h after each meal. 
Results: Except that the females had higher HDL-C level than the males in the fasting and non-fasting states, the gender difference in other lipid parameters did not reach statistical significance at any time-point. TG and RC levels increased while LDL-C level decreased significantly after three meals (P＜0.05). Percent reductions in non-fasting LDL-C levels after lunch and dinner seemed to be greater than that after breakfast and were around 20%. Percent increases in non-fasting TG and RLP-C levels reached the peak after lunch, and were＞70% and＞100%, respectively. Patients with TG level ≥2.0 mmol/L after lunch had significantly greater absolute reduction in LDL-C level than those with TG level < 2.0 mmol/L after lunch ( 0.69 vs 0.36 mmol/L, P＜0.01). There was a significantly negative correlation between absolute change in LDL-C level and that in TG level (r = -0.32) or RC level (r = -0.67) after lunch (both P＜0.01). There was no significant difference in TC and HDL-C levels before and after meals. Percent reductions in non-fasting nonHDL-C levels were small and the largest ones were found after dinner and did not exceed 10.1%. 
Conclusion: 
LDL-C level decreased significantly after three meals, especially in patients with higher TG level after lunch. The changes in TC, HDL-C and nonHDL-C levels after three meals were small. It indicated that non-fasting level of nonHDL-C level was more stable than that of LDL-C level after three meals in Chinese patients with cardiovascular diseases.