AUTHOR=Wang Zeyu , Pan Xin , Xu Hong , Wu You , Jia Xiaomin , Fang Yiling , Lu Yi , Xu Yawei , Zhang Ji , Su Yang 

TITLE=Serum Soluble ST2 Is a Valuable Prognostic Biomarker in Patients With Acute Heart Failure

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.812654

DOI=10.3389/fcvm.2022.812654

ISSN=2297-055X

ABSTRACT=<sec><title>Background</title><p>This study aimed to investigate the clinical utility of different soluble suppression of tumorigenicity 2 (sST2) levels in assessing the severity and prognosis of patients with acute heart failure (AHF).</p></sec><sec><title>Methods</title><p>This was a prospective cohort study. Three hundred and thirty-one consecutively enrolled AHF patients from March 2018 to November 2019 were divided into 3 subgroups according to sST2 levels: T1 (1.15–7.70 ng/ml; <italic>N</italic> = 110), T2 (7.71–17.24 ng/ml; <italic>N</italic> = 111), and T3 (17.26–47.42 ng/ml; <italic>N</italic> = 110). The patients were followed up for a median period of 21.0 months for the development of the primary endpoint. Cox proportional hazards model was performed to evaluate the prognostic value of sST2 for the clinical outcomes.</p></sec><sec><title>Results</title><p>The mean age of patients was 69 years (range, 34–93 years), and 70.4% were male. During the follow-up period, 63 participants died. Patients with higher sST2 levels had lower left ventricular ejection fraction (correlation = −0.119, <italic>P</italic> = 0.031), and higher New York Heart Association classification (correlation = 0.443, <italic>P</italic> &lt; 0.001) and N-terminal pro-B type natriuretic peptide (NT-proBNP) levels (correlation = 0.392, <italic>P</italic> &lt; 0.001). Higher sST2 was also associated with creatinine, urea nitrogen, hemoglobin, and left ventricular mass index. Multivariate analysis revealed that sST2 (per log unit, hazard ratio: 2.174, 95% confidence interval [CI] 1.012–4.67, <italic>P</italic> = 0.047) and NT-proBNP (per log unit, HR 2.171, 95%CI 1.169–4.032, <italic>P</italic> &lt; 0.001) were independent risk factors for the primary outcome in all patients with AHF.</p></sec><sec><title>Conclusion</title><p>sST2 can provide prognostic information in AHF. The higher the sST2 level in patients with AHF, the higher the incidence of cardiovascular death.</p></sec>